Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery
文献类型：期刊论文
| 作者 | He P ; Tang ZH ; Lin L ; Deng MX ; Pang X ; Zhuang XL ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:4页码:547-556 |
| 关键词 | DRUG-DELIVERY IN-VITRO CHITOSAN MACROMOLECULES NANOPARTICLES ENCAPSULATION CHALLENGES COPOLYMERS STABILITY HYDROGELS |
| ISSN号 | 1616-5187 |
| 通讯作者 | deng mx |
| 中文摘要 | biodegradable and ph-sensitive peas based on dual amino acids are designed, synthesized, and characterized. insulin can be loaded into the pea microspheres by a solid-in-oil-in-oil technique with high encapsulation efficiency. the feasibility of pea microspheres as oral insulin delivery carriers is evaluated in vitro and in vivo. the hydrophobic leucine groups on pea seem to play an important role in the ph-dependent release mechanism and cytotoxicity of pea microspheres. oral administration of insulin-loaded pea microspheres to streptozotocin-induced diabetic rats at 60 iu kg-1 is able to reduce fasting plasma glucose levels to 49.4%. these results indicate that pea microspheres are potential new vehicles for insulin oral delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302622200015 |
| 公开日期 | 2013-06-03 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48253]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | He P,Tang ZH,Lin L,et al. Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery[J]. macromolecular bioscience,2012,12(4):547-556. |
| APA | He P.,Tang ZH.,Lin L.,Deng MX.,Pang X.,...&Chen XS.(2012).Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery.macromolecular bioscience,12(4),547-556. |
| MLA | He P,et al."Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery".macromolecular bioscience 12.4(2012):547-556. |
入库方式： OAI收割
来源：长春应用化学研究所
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