Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex
文献类型：期刊论文
| 作者 | Jiang, M ; Zhu, J ; Liu, YP ; Yang, MP ; Tian, CP ; Jiang, S ; Wang, YH ; Guo, H ; Wang, KY ; Shu, YS |
| 刊名 | PLOS BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:5页码:-e1001324 |
| ISSN号 | 1545-7885 |
| 关键词 | TEMPORAL-LOBE EPILEPSY TERM SYNAPTIC PLASTICITY DENTATE GRANULE CELLS ACTIVITY IN-VIVO TRANSMITTER RELEASE INHIBITORY INTERNEURONS REDUCED INHIBITION ENTORHINAL CORTEX PYRAMIDAL CELLS LAYER-III |
| 通讯作者 | Wang, KY (reprint author), Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China.,wang_kaiyan@yahoo.com.cn ; shu@ion.ac.cn |
| 英文摘要 | Down-regulation of GABAergic inhibition may result in the generation of epileptiform activities. Besides spike-triggered synchronous GABA release, changes in asynchronous release (AR) following high-frequency discharges may further regulate epileptiform activities. In brain slices obtained from surgically removed human neocortical tissues of patients with intractable epilepsy and brain tumor, we found that AR occurred at GABAergic output synapses of fast-spiking (FS) neurons and its strength depended on the type of connections, with FS autapses showing the strongest AR. In addition, we found that AR depended on residual Ca2+ at presynaptic terminals but was independent of postsynaptic firing. Furthermore, AR at FS autapses was markedly elevated in human epileptic tissue as compared to non-epileptic tissue. In a rat model of epilepsy, we found similar elevation of AR at both FS autapses and synapses onto excitatory neurons. Further experiments and analysis showed that AR elevation in epileptic tissue may result from an increase in action potential amplitude in the FS neurons and elevation of residual Ca2+ concentration. Together, these results revealed that GABAergic AR occurred at both human and rat neocortex, and its elevation in epileptic tissue may contribute to the regulation of epileptiform activities. |
| 学科主题 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 资助信息 | 973 Program [2011CBA00400]; National Natural Science Foundation of China [31025012]; Shanghai Pujiang Program [07PJ14108]; SA-SIBS; Hundreds of Talents Program; Strategic Priority Research Program [XDA01020304]; State Key Laboratory of Neuroscience; Chinese Academy of Sciences [KSCX2-YW-R-102] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2479]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Jiang, M,Zhu, J,Liu, YP,et al. Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex[J]. PLOS BIOLOGY,2012,10(5):-e1001324. |
| APA | Jiang, M.,Zhu, J.,Liu, YP.,Yang, MP.,Tian, CP.,...&Shu, YS.(2012).Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex.PLOS BIOLOGY,10(5),-e1001324. |
| MLA | Jiang, M,et al."Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex".PLOS BIOLOGY 10.5(2012):-e1001324. |
入库方式： OAI收割
来源：上海神经科学研究所
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