Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration
文献类型：期刊论文
| 作者 | Zhang, X
|
| 刊名 | CELL
 |
| 出版日期 | 2012 |
| 卷号 | 149期号:7页码:1549-1564 |
| 关键词 | FACTOR HOMOLOGOUS FACTORS MULTIPOLAR STAGE NERVOUS-SYSTEM DOUBLECORTIN MICE OUTGROWTH MEMORY MAP1B NUCLEOKINESIS TRANSLOCATION |
| ISSN号 | 0092-8674 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | Secretory fibroblast growth factors (FGFs) and their receptors are known for their regulatory function in the early stages of neural development. FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a candidate gene for syndromal and nonspecific forms of X-chromosome-linked mental retardation (XLMR). However, its function during development remains unclear. We show that FGF13 acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex. FGF13 is enriched in axonal growth cones and interacts directly with microtubules. Furthermore, FGF13 polymerizes tubulins and stabilizes microtubules. The loss of FGF13 impairs neuronal polarization and increases the branching of axons and leading processes. Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory, which is correlated to XLMR patients' intellectual disability. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 收录类别 | SCI |
| 资助信息 | NNSFC [31130066]; MOST [2011CBA00400, 2009CB522005] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2481]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, X. Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration[J]. CELL,2012,149(7):1549-1564. |
| APA | Zhang, X.(2012).Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration.CELL,149(7),1549-1564. |
| MLA | Zhang, X."Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration".CELL 149.7(2012):1549-1564. |
入库方式： OAI收割
来源：上海神经科学研究所
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