Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development
文献类型：期刊论文
| 作者 | Xu, JY ; Qi, X ; Gong, JF ; Yu, MY ; Zhang, FX ; Sha, HB ; Gao, X |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:4页码:-e32554 |
| 关键词 | BONE MORPHOGENETIC PROTEIN-4 URINARY-TRACT DEVELOPMENT SONIC-HEDGEHOG CONGENITAL-ANOMALIES MOUSE URETER BRANCHING MORPHOGENESIS PERISTALTIC MACHINERY VESICOURETERAL REFLUX KIDNEY DEVELOPMENT EXPRESSION |
| ISSN号 | 1932-6203 |
| 通讯作者 | Xu, JY (reprint author), Nanjing Univ, Model Anim Res Ctr, MOE Key Lab Model Anim Dis Study, Nanjing, Jiangsu, Peoples R China.,gaoxiang@nju.edu.cn |
| 英文摘要 | Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract development although the detailed regulation of its activity in this process remains unclear. Here we report that follistatiri-like 1 (Fstl1), encoding a secreted extracellular glycoprotein, is expressed in developing ureter and antagonizes BMP signaling activity. Mouse embryos carrying disrupted Fstl1 gene displayed prominent hydroureter arising from proximal segment and tireterovesical junction defects. These defects were associated with significant reduction in ureteric epithelial cell proliferation at E15.5 and E16.5 as well as absence of subepithelial ureteral mesenchymal cells in the urinary tract at E16.5 and E18.5. At the molecular level, increased BMP signaling was found in Fstl1 deficient ureters, indicated by elevated pSmad1/5/8 activity. in vitro study also indicated that Fstl1 can directly bind to ALK6 which is specifically expressed in ureteric epithelial cells in developing ureter. Furthermore, Sonic hedgehog (SHH) signaling, which is crucial for differentiation of ureteral subepithelial cell proliferation, was also impaired in Fstl1(-/-) ureter. Altogether, our data suggest that Fstl1 is essential in maintaining normal ureter development by antagonizing BMP signaling. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | MOST (The Ministry of Science and Technology) [2011CB944104, 2011BAI15B02, 2011ZX09307-302-02]; NSFC (The National Science Foundation of China) [30825024] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2483]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, JY,Qi, X,Gong, JF,et al. Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development[J]. PLOS ONE,2012,7(4):-e32554. |
| APA | Xu, JY.,Qi, X.,Gong, JF.,Yu, MY.,Zhang, FX.,...&Gao, X.(2012).Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development.PLOS ONE,7(4),-e32554. |
| MLA | Xu, JY,et al."Fstl1 Antagonizes BMP Signaling and Regulates Ureter Development".PLOS ONE 7.4(2012):-e32554. |
入库方式： OAI收割
来源：上海神经科学研究所
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