MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons
文献类型：期刊论文
| 作者 | Zhang, X
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:37页码:12673-12683 |
| 关键词 | RADIAL MIGRATION INTERNEURON MIGRATION CEREBRAL-CORTEX ACETYLTRANSFERASE DOUBLECORTIN NEOCORTEX MOTILITY PROTEIN HDAC6 NUCLEOKINESIS |
| ISSN号 | 0270-6474 |
| 通讯作者 | Bao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,baolan@sibs.ac.cn |
| 英文摘要 | Neuronal migration is a fundamental process during the development of the cerebral cortex and is regulated by cytoskeletal components. Microtubule dynamics can be modulated by posttranslational modifications to tubulin subunits. Acetylation of alpha-tubulin at lysine 40 is important in regulating microtubule properties, and this process is controlled by acetyltransferase and deacetylase. MEC-17 is a newly discovered alpha-tubulin acetyltransferase that has been found to play a major role in the acetylation of alpha-tubulin in different species in vivo. However, the physiological function of MEC-17 during neural development is largely unknown. Here, we report that MEC-17 is critical for the migration of cortical neurons in the rat. MEC-17 was strongly expressed in the cerebral cortex during development. MEC-17 deficiency caused migratory defects in the cortical projection neurons and interneurons, and perturbed the transition of projection neurons from the multipolar stage to the unipolar/bipolar stage in the intermediate zone of the cortex. Furthermore, knockdown of alpha-tubulin deacetylase HDAC6 or overexpression of tubulin(K40Q) to mimic acetylated alpha-tubulin could reduce the migratory and morphological defects caused by MEC-17 deficiency in cortical projection neurons. Thus, MEC-17, which regulates the acetylation of alpha-tubulin, appears to control the migration and morphological transition of cortical neurons. This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30930044]; National Basic Research Program of China [2010CB912001] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2488]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, X. MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons[J]. JOURNAL OF NEUROSCIENCE,2012,32(37):12673-12683. |
| APA | Zhang, X.(2012).MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons.JOURNAL OF NEUROSCIENCE,32(37),12673-12683. |
| MLA | Zhang, X."MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons".JOURNAL OF NEUROSCIENCE 32.37(2012):12673-12683. |
入库方式： OAI收割
来源：上海神经科学研究所
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