Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis
文献类型：期刊论文
| 作者 | Zhao, JL ; He, H ; Zhou, KC ; Ren, YG ; Shi, ZX ; Wu, ZY ; Wang, YZ ; Lu, YC ; Jiao, JW |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:7页码:-e41506 |
| 关键词 | HUMAN GLIOBLASTOMA CELLS FUNCTIONAL-NEURONS MALIGNANT GLIOMAS HUMAN FIBROBLASTS GROWTH SUPPRESSION APOPTOSIS ADULTS CYCLE |
| ISSN号 | 1932-6203 |
| 通讯作者 | Zhao, JL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai, Peoples R China.,yichenglucz@gmail.com ; jwjiao@ioz.ac.cn |
| 英文摘要 | Recent findings have demonstrated that the overexpression of lineage-specific transcription factors induces cell fate changes among diverse cell types. For example, neurons can be generated from mouse and human fibroblasts. It is well known that neurons are terminally differentiated cells that do not divide. Therefore, we consider how to induce glioma cells to become neurons by introducing transcription factors. Here, we describe the efficient generation of induced neuronal (iN) cells from glioma cells by the infection with three transcription factors: Ascl1, Brn2 and Ngn2 (ABN). iN cells expressed multiple neuronal markers and fired action potentials, similar to the properties of authentic neurons. Importantly, the proliferation of glioma cells following ABN overexpression was dramatically inhibited in both in vitro and in vivo experiments. In addition, iN cells that originated from human glioma cells did not continue to grow when they were sorted and cultured in vitro. The strategies by which glioma cells are induced to become neurons may be used to clinically study methods for inhibiting tumor growth. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CBA00402]; "Strategic Priority Research Program" of the Chinese Academy of Sciences [XDA01020301]; National Natural Science Foundation of China [30930094]; Hundred Talent Program |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2492]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhao, JL,He, H,Zhou, KC,et al. Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis[J]. PLOS ONE,2012,7(7):-e41506. |
| APA | Zhao, JL.,He, H.,Zhou, KC.,Ren, YG.,Shi, ZX.,...&Jiao, JW.(2012).Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis.PLOS ONE,7(7),-e41506. |
| MLA | Zhao, JL,et al."Neuronal Transcription Factors Induce Conversion of Human Glioma Cells to Neurons and Inhibit Tumorigenesis".PLOS ONE 7.7(2012):-e41506. |
入库方式： OAI收割
来源：上海神经科学研究所
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