P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth
文献类型：期刊论文
| 作者 | Xu, Q ; Yang, GY ; Liu, N ; Xu, P ; Chen, YL ; Zhou, Z ; Luo, ZG ; Ding, XY |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 586期号:13页码:1803-1812 |
| ISSN号 | 0014-5793 |
| 关键词 | P-TYPE ATPASE NERVE GROWTH-FACTOR PHOSPHOLIPID TRANSLOCATION SUBCELLULAR-LOCALIZATION SACCHAROMYCES-CEREVISIAE DRS2P PROTEIN DIFFERENTIATION IDENTIFICATION ESTABLISHMENT |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Grad Sch, State Key Lab Cell Biol, Inst Biochem & Cell Biol,SIBS, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sibs.ac.cn |
| 英文摘要 | P-4-ATPases are lipid flippases that transport phospholipids across cellular membranes, playing vital roles in cell function. In humans, the disruption of the P-4-ATPase ATP8A2 gene causes a severe neurological phenotype. Here, we found that Atp8a2 mRNA was highly expressed in PC12 cells, hippocampal neurons and the brain. Overexpression of ATP8A2 increased the length of neurite outgrowth in NGF-induced PC12 cells and in primary cultures of rat hippocampal neurons. Inducing the loss of function of CDC50A in hippocampal neurons via RNA interference reduced neurite outgrowth, and the co-overexpression of CDC50A and ATP8A2 in PC12 cells enhanced NGF-induced neurite outgrowth. These results indicate that ATP8A2, acting in synergy with CDC50A, performs an important role in neurite outgrowth in neurons. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 资助信息 | National Basic Research Program of China [2009CB941103, 2011CBA01105]; Science and Technology Planning Project of Shanghai, China [11140903400, 10ZR1435400]; Major National Science and Technology Projects [2011ZX09307-302-01]; Sino German cooperation project [GZ517]; National Natural Science Foundation of China [31000624, 30825013]; Knowledge Innovation Program of Shanghai Institutes for Biological Sciences [2010KIP302] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2493]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, Q,Yang, GY,Liu, N,et al. P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth[J]. FEBS LETTERS,2012,586(13):1803-1812. |
| APA | Xu, Q.,Yang, GY.,Liu, N.,Xu, P.,Chen, YL.,...&Ding, XY.(2012).P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth.FEBS LETTERS,586(13),1803-1812. |
| MLA | Xu, Q,et al."P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth".FEBS LETTERS 586.13(2012):1803-1812. |
入库方式： OAI收割
来源：上海神经科学研究所
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