Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
文献类型：期刊论文
| 作者 | Du, JL
|
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2012 |
| 卷号 | 23期号:6页码:1189-1202 |
| 关键词 | BRAIN ZEBRAFISH CELLS REVEALS CNS MACROPHAGES ACTIVATION PARENCHYMA EXPRESSION APOPTOSIS |
| ISSN号 | 1534-5807 |
| 通讯作者 | Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn |
| 英文摘要 | Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding neurons are still unclear. Using in vivo time-lapse imaging of both microglial morphology and neuronal activity in the optic tectum of larval zebrafish, we found that neuronal activity steers resting microglial processes and facilitates their contact with highly active neurons. This process requires the activation of pannexin-1 hemichannels on neurons. Reciprocally, such resting microglia-neuron contact reduces both spontaneous and visually evoked activities of contacted neurons. Our findings reveal an instructive role for neuronal activity in resting microglial motility and suggest the function for microglia in homeostatic regulation of neuronal activity in the healthy brain. |
| 学科主题 | Cell Biology ; Developmental Biology |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CBA00400, 2012CB945101]; Strategic Priority Research Program [XDB02040300]; Chinese Academy of Sciences; Shanghai government [07pj14107]; General Research Fund (GRF) grants; Research Grants Council of the HKSAR [HKUST6/CRF/09] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2497]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Du, JL. Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo[J]. DEVELOPMENTAL CELL,2012,23(6):1189-1202. |
| APA | Du, JL.(2012).Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo.DEVELOPMENTAL CELL,23(6),1189-1202. |
| MLA | Du, JL."Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo".DEVELOPMENTAL CELL 23.6(2012):1189-1202. |
入库方式： OAI收割
来源：上海神经科学研究所
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