Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons
文献类型：期刊论文
| 作者 | Zhang, XH
|
| 刊名 | JOURNAL OF PHYSIOLOGY-LONDON
 |
| 出版日期 | 2012 |
| 卷号 | 590期号:19页码:4917-4932 |
| 关键词 | LONG-TERM POTENTIATION ELEMENT-BINDING PROTEIN SYNAPTIC PLASTICITY POSTNATAL ONTOGENESIS RECEPTOR TRAFFICKING KINASE CASCADE MOUSE-BRAIN AREA CA1 MICE ACTIVATION |
| ISSN号 | 0022-3751 |
| 通讯作者 | Zhang, WPJ (reprint author), Mil Med Coll 2, Dept Pathophysiol, Shanghai 200433, Peoples R China.,wzhang@smmu.edu.cn |
| 英文摘要 | Key points Zinc finger and BTB domain-containing protein 20 (Zbtb20) plays a critical role in hippocampal development. In the present study, we generated mutant mice in which Zbtb20 knockout was restricted to mature CA1 pyramidal cells of the hippocampus. Conditionally deleting Zbtb20 specifically in mature CA1 pyramidal neurons impaired LTP and memory. We found that Zbtb20 controls memory formation and synaptic plasticity by regulating NMDAR activity, and activation of ERK and CREB. Abstract The mammalian hippocampus harbours neural circuitry that is crucial for associative learning and memory. The mechanisms that underlie the development and regulation of this complex circuitry are not fully understood. Our previous study established an essential role for the zinc finger protein Zbtb20 in the specification of CA1 field identity in the developing hippocampus. Here, we show that conditionally deleting Zbtb20 specifically in mature CA1 pyramidal neurons impaired hippocampus-dependent memory formation, without affecting hippocampal architecture or the survival, identity and basal excitatory synaptic activity of CA1 pyramidal neurons. We demonstrate that mature CA1-specific Zbtb20 knockout mice exhibited reductions in long-term potentiation (LTP) and NMDA receptor (NMDAR)-mediated excitatory post-synaptic currents. Furthermore, we show that activity-induced phosphorylation of ERK and CREB is impaired in the hippocampal CA1 of Zbtb20 mutant mice. Collectively, these results indicate that Zbtb20 in mature CA1 plays an important role in LTP and memory by regulating NMDAR activity, and activation of ERK and CREB. |
| 学科主题 | Neurosciences & Neurology ; Physiology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [31140090, 31025013, 30970589, 31128008, 30800375]; National Key Basic Research Program of China [2012CB524904]; Shanghai Municipal Science and Technology Commission [11XD1406500]; SA-SIBS Scholarship Program; Shanghai Postdoctoral Scientific Program [12R21418000] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2498]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, XH. Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons[J]. JOURNAL OF PHYSIOLOGY-LONDON,2012,590(19):4917-4932. |
| APA | Zhang, XH.(2012).Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons.JOURNAL OF PHYSIOLOGY-LONDON,590(19),4917-4932. |
| MLA | Zhang, XH."Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons".JOURNAL OF PHYSIOLOGY-LONDON 590.19(2012):4917-4932. |
入库方式： OAI收割
来源：上海神经科学研究所
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