The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila
文献类型：期刊论文
| 作者 | Guo, AK
|
| 刊名 | LEARNING & MEMORY
 |
| 出版日期 | 2012 |
| 卷号 | 19期号:10页码:478-486 |
| 关键词 | MUSHROOM BODY NEURONS ORBITOFRONTAL CORTEX TERM-MEMORY MELANOGASTER EXTINCTION BRAIN ACQUISITION SUPPRESSES BEHAVIOR LESIONS |
| ISSN号 | 1072-0502 |
| 通讯作者 | Guo, AK (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,akguo@ion.ac.cn |
| 英文摘要 | Reversal learning has been widely used to probe the implementation of cognitive flexibility in the brain. Previous studies in monkeys identified an essential role of the orbitofrontal cortex (OFC) in reversal learning. However, the underlying circuits and molecular mechanisms are poorly understood. Here, we use the T-maze to investigate the neural mechanism of olfactory reversal learning in Drosophila. By adding a reversal training cycle to the classical learning protocol, we show that wild-type flies are able to reverse their choice according to the alteration of conditioned stimulus (CS)-unconditioned stimulus (US) contingency. The reversal protocol induced a specific suppression of the initial memory, an effect distinct from memory decay or extinction. GABA down-regulation in the anterior paired lateral (APL) neurons, which innervate the mushroom bodies (MBs), eliminates this suppression effect and impairs normal reversal. These findings reveal that inhibitory regulation from the GABAergic APL neurons facilitates olfactory reversal learning by suppressing initial memory in Drosophila. |
| 学科主题 | Neurosciences & Neurology ; Psychology |
| 收录类别 | SCI |
| 资助信息 | 973 program [G20000 77800, 2006CB806600, 2006CB911003, 2011CBA00400]; National Science Foundation of China [30921064, 90820008, 31130027]; Important Intersectional Disciplines in the Knowledge Innovation Engineering Department of the Chinese Academy of Sciences [KJCX1-09-03, KSCX2-YW-R-28] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2504]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Guo, AK. The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila[J]. LEARNING & MEMORY,2012,19(10):478-486. |
| APA | Guo, AK.(2012).The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila.LEARNING & MEMORY,19(10),478-486. |
| MLA | Guo, AK."The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila".LEARNING & MEMORY 19.10(2012):478-486. |
入库方式： OAI收割
来源：上海神经科学研究所
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