Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord
文献类型：期刊论文
| 作者 | Guo, Z ; Zhao, CL ; Huang, MG ; Huang, TW ; Fan, MR ; Xie, ZQ ; Chen, Y ; Zhao, XL ; Xia, GN ; Geng, JL ; Cheng, LP |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:25页码:8509-8520 |
| 关键词 | IONOTROPIC GLUTAMATE RECEPTORS NEUROPEPTIDE YY1 RECEPTOR LAMINAE-I-III GABAERGIC NEURONS SYNAPTIC-TRANSMISSION MOLECULAR-MECHANISMS INTERNATIONAL UNION SELECTOR GENE Y-RECEPTOR CELL FATE |
| ISSN号 | 0270-6474 |
| 通讯作者 | Cheng, LP (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lpcheng@ion.ac.cn |
| 英文摘要 | Establishing the pattern of expression of transmitters and peptides as well as their receptors in different neuronal types is crucial for understanding the circuitry in various regions of the brain. Previous studies have demonstrated that the transmitter and peptide phenotypes in mouse dorsal spinal cord neurons are determined by the transcription factors Tlx1/3 and Ptf1a. Here we show that these transcription factors also determine the expression of two distinct sets of transmitter and peptide receptor genes in this region. We have screened the expression of 78 receptor genes in the spinal dorsal horn by in situ hybridization. We found that receptor genes Gabra1, Gabra5, Gabrb2, Gria3, Grin3a, Grin3b, Galr1, and Npy1r were preferentially expressed in Tlx3-expressing glutamatergic neurons and their derivatives, and deletion of Tlx1 and Tlx3 resulted in the loss of expression of these receptor genes. Furthermore, we obtained genetic evidence that Tlx3 uses distinct pathways to control the expression of receptor genes. We also found that receptor genes Grm3, Grm4, Grm5, Grik1, Grik2, Grik3, and Sstr2 were mainly expressed in Pax2-expressing GABAergic neurons in the spinal dorsal horn, and their expression in this region was abolished or markedly reduced in Ptf1a and Pax2 deletion mutant mice. Together, our studies indicate that Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord, are also responsible for controlling the expression of two distinct sets of transmitter and peptide receptor genes. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 Program from The Ministry of Science and Technology of China [2011CBA00400]; "Strategic Priority Research Program" of the Chinese Academy of Sciences [XDA01020306]; 973 Program [2007CB947102] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2506]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Guo, Z,Zhao, CL,Huang, MG,et al. Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord[J]. JOURNAL OF NEUROSCIENCE,2012,32(25):8509-8520. |
| APA | Guo, Z.,Zhao, CL.,Huang, MG.,Huang, TW.,Fan, MR.,...&Cheng, LP.(2012).Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord.JOURNAL OF NEUROSCIENCE,32(25),8509-8520. |
| MLA | Guo, Z,et al."Tlx1/3 and Ptf1a Control the Expression of Distinct Sets of Transmitter and Peptide Receptor Genes in the Developing Dorsal Spinal Cord".JOURNAL OF NEUROSCIENCE 32.25(2012):8509-8520. |
入库方式： OAI收割
来源：上海神经科学研究所
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