TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKII alpha in Rat Hippocampal Neurons
文献类型：期刊论文
| 作者 | He, ZH ; Jia, CX ; Feng, SJ ; Zhou, KC ; Tai, YL ; Bai, X ; Wang, YZ |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:27页码:9383-9395 |
| 关键词 | PROTEIN-KINASE-II PHOSPHATIDYLINOSITOL 4 5-BISPHOSPHATE SIGNAL-TRANSDUCTION INTRACELLULAR CA2+ CALCIUM REGULATION PYRAMIDAL NEURONS TRK RECEPTORS BDNF TRANSCRIPTION CELLS |
| ISSN号 | 0270-6474 |
| 通讯作者 | Wang, YZ (reprint author), 320 Yueyang Rd, Shanghai 200031, Peoples R China.,yzwang@ion.ac.cn |
| 英文摘要 | Neurotrophin-3 (NT-3) plays numerous important roles in the CNS and the elevation of intracellular Ca2+ ([Ca2+](i)) is critical for these functions of NT-3. However, the mechanism by which NT-3 induces [Ca2+](i) elevation remains largely unknown. Here, we found that transient receptor potential canonical (TRPC) 5 protein and TrkC, the NT-3 receptor, exhibited a similar temporal expression in rat hippocampus and cellular colocalization in hippocampal neurons. Stimulation of the neurons by NT-3 induced a nonselective cation conductance and PLC gamma-dependent [Ca2+](i) elevation, which were both blocked when TRPC5, but not TRPC6 channels, were inhibited. Moreover, the Ca2+ influx through TRPC5 induced by NT-3 inhibited the neuronal dendritic growth through activation of calmodulin-dependent kinase (CaMK) II alpha. In contrast, the Ca2+ influx through TRPC6 induced by NT-4 promoted the dendritic growth. Thus, TRPC5 acts as a novel and specific mediator for NT-3 to regulate dendrite development through CaMKII alpha. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CB00400]; National Natural Science Foundation of China [81130081] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2508]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | He, ZH,Jia, CX,Feng, SJ,et al. TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKII alpha in Rat Hippocampal Neurons[J]. JOURNAL OF NEUROSCIENCE,2012,32(27):9383-9395. |
| APA | He, ZH.,Jia, CX.,Feng, SJ.,Zhou, KC.,Tai, YL.,...&Wang, YZ.(2012).TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKII alpha in Rat Hippocampal Neurons.JOURNAL OF NEUROSCIENCE,32(27),9383-9395. |
| MLA | He, ZH,et al."TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKII alpha in Rat Hippocampal Neurons".JOURNAL OF NEUROSCIENCE 32.27(2012):9383-9395. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。