Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Huang, FD
|
| 刊名 | NEUROBIOLOGY OF DISEASE
 |
| 出版日期 | 2013 |
| 卷号 | 51期号:1页码:161-167 |
| 关键词 | INTRANEURONAL-A-BETA DENDRITIC SPINE LOSS CALCIUM-CHANNEL AMYLOID-BETA COGNITIVE IMPAIRMENT SYNAPTIC DEPRESSION TRANSGENIC MICE PROTEIN EXPRESSION BRUCHPILOT |
| ISSN号 | 0969-9961 |
| 通讯作者 | Sun, XJ (reprint author), Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Neurol, Shanghai 200233, Peoples R China.,sunxj@sohu.com |
| 英文摘要 | The accumulation of beta amyloid (A beta) can cause synaptic impairments, but the characteristics and mechanisms of the synaptic impairment induced by the accumulation of A beta in Alzheimer's disease (AD) remain unclear. In identified single neurons in a newly developed Drosophila AD model, in which A beta accumulates intraneuronally, we found an age-dependent reduction in the synaptic vesicle release probability that was associated with a decrease in the density of presynaptic calcium channel clusters and an increase in the presynaptic and postsynaptic contact length. Moreover, these alterations occurred in the absence of presynaptic bouton loss. In addition, we found that A beta expression also produced an age-dependent decrease in the amount of Bruchpilot (Brp), which plays an important role in controlling Ca2+ channel clustering and synaptic vesicle release in the presynaptic active zone. Our study indicates that the chronic accumulation of intraneuronal A beta can induce functional and structural changes in the presynaptic active zone prior to a loss of presynaptic buttons in the same neuron. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 program [2013CB530900, 2011CBA00408]; National Natural Science Foundation of China [31171014] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2514]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Huang, FD. Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease[J]. NEUROBIOLOGY OF DISEASE,2013,51(1):161-167. |
| APA | Huang, FD.(2013).Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease.NEUROBIOLOGY OF DISEASE,51(1),161-167. |
| MLA | Huang, FD."Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease".NEUROBIOLOGY OF DISEASE 51.1(2013):161-167. |
入库方式： OAI收割
来源：上海神经科学研究所
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