Heterosynaptic long-term depression mediated by ATP released from astrocytes
文献类型：期刊论文
| 作者 | Chen, JD ; Tan, ZB ; Zeng, L ; Zhang, XX ; He, Y ; Gao, W ; Wu, XM ; Li, YJ ; Bu, BT ; Wang, W ; Duan, SM |
| 刊名 | GLIA
 |
| 出版日期 | 2013 |
| 卷号 | 61期号:2页码:178-191 |
| 关键词 | CULTURED HIPPOCAMPAL-NEURONS GLIAL-CELLS SYNAPTIC-TRANSMISSION D-SERINE GLUTAMATE RELEASE CALCIUM WAVES POTENTIATION STIMULATION PLASTICITY RECEPTOR |
| ISSN号 | 0894-1491 |
| 通讯作者 | Duan, SM (reprint author), Zhejiang Univ, Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China,Dept Neurobiol,Key Lab Med Neur, Hangzhou 310003, Zhejiang, Peoples R China.,duanshumin@zju.edu.cn |
| 英文摘要 | Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induced ATP release from astrocytes that suppresses transmitter release from untetanized synaptic terminals via activation of P2Y receptors. Selective stimulation of astrocytes expressing channelrhodopsin-2, a light-gated cation channel permeable to Ca2+, resulted in LTD of synapses on neighboring neurons. This synaptic modification required Ca2+ elevation in astrocytes and activation of P2Y receptors, but not N-methyl-D-aspartate receptors. Furthermore, blocking P2Y receptors or buffering astrocyte intracellular Ca2+ at a low level prevented hLTD without affecting LTP induced by SC stimulation. Thus, astrocyte activation is both necessary and sufficient for mediating hLTD accompanying LTP induction, strongly supporting the notion that astrocytes actively participate in activity-dependent synaptic plasticity of neural circuits. (c) 2012 Wiley Periodicals, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Major State Basic Research Program of China [2011CB504400, 2011CBA00400]; National Natural Science Foundation of China [30730037, 31190060] |
| 语种 | 英语 |
| 公开日期 | 2013-06-04 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2517]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Chen, JD,Tan, ZB,Zeng, L,et al. Heterosynaptic long-term depression mediated by ATP released from astrocytes[J]. GLIA,2013,61(2):178-191. |
| APA | Chen, JD.,Tan, ZB.,Zeng, L.,Zhang, XX.,He, Y.,...&Duan, SM.(2013).Heterosynaptic long-term depression mediated by ATP released from astrocytes.GLIA,61(2),178-191. |
| MLA | Chen, JD,et al."Heterosynaptic long-term depression mediated by ATP released from astrocytes".GLIA 61.2(2013):178-191. |
入库方式： OAI收割
来源：上海神经科学研究所
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