Analytical calculation of protein production distributions in models of clustered protein expression
文献类型：期刊论文
| 作者 | Feng HD ; Hensel Z ; Xiao J ; Wang J |
| 刊名 | physical review e
 |
| 出版日期 | 2012 |
| 卷号 | 85期号:3页码:文献号: 031904 |
| 关键词 | GENE-EXPRESSION REGULATORY NETWORKS FLUCTUATIONS MOLECULE ULTRASENSITIVITY KINETICS CELLS |
| ISSN号 | 1539-3755 |
| 通讯作者 | feng hd |
| 中文摘要 | a theoretical framework is presented, which derives chemical master equations for the number of protein molecules produced in a given time window, it is applied to derive analytical solutions that describe protein production distributions for the random bursting model (with an exponential or geometric burst-size distribution) and the clustering model. this distribution is experimentally observable using recently developed, single-molecule gene expression experiments. furthermore, intrinsic stochasticity in a gene's expression can be calculated from protein production distributions using a new, time-dependent noise curve analysis. different models of gene expression are compared with respect to their protein production distributions and intrinsic stochasticity, revealing the effects of molecular memory and burstlike expression on fluctuations in gene expression. it is distinct from and provides major advantages over measurements of steady-state concentrations. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301340800008 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48275]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng HD,Hensel Z,Xiao J,et al. Analytical calculation of protein production distributions in models of clustered protein expression[J]. physical review e,2012,85(3):文献号: 031904. |
| APA | Feng HD,Hensel Z,Xiao J,&Wang J.(2012).Analytical calculation of protein production distributions in models of clustered protein expression.physical review e,85(3),文献号: 031904. |
| MLA | Feng HD,et al."Analytical calculation of protein production distributions in models of clustered protein expression".physical review e 85.3(2012):文献号: 031904. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。