pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)-grafted comb copolymers
文献类型：期刊论文
| 作者 | Ding JX ; He CL ; Xiao CS ; Chen J ; Zhuang XL ; Chen XS |
| 刊名 | macromolecular research
 |
| 出版日期 | 2012 |
| 卷号 | 20期号:3页码:292-301 |
| 关键词 | TRANSFER RADICAL POLYMERIZATION INTRACELLULAR DELIVERY BLOCK-COPOLYMER MULTIFUNCTIONAL NANOCARRIERS GENE DELIVERY LIVER-CANCER MICELLES NANOPARTICLES RELEASE DOXORUBICIN |
| ISSN号 | 1598-5032 |
| 通讯作者 | chen xs |
| 中文摘要 | five ph-responsive alkyne-poly(2-aminoethyl methacrylate)-graft-poly(l-glutamic acid) (alkyne-pama-g-plga) comb copolymers were synthesized through the ring-opening polymerization (rop) of gamma-benzyl-l-glutamate n-carboxyanhydride (blg nca) and the subsequent deprotection of benzyl group from blg unit. the chemical structures of copolymers were confirmed by proton nuclear magnetic resonance spectra (h-1 nmr) and fourier transform infrared spectroscopy (ftir). the pyrene-probe-based fluorescence technique and transmission electron microscopy (tem) measurements revealed that the comb copolymers could spontaneously self-assemble into micellar or vesicular nanoparticles in phosphate buffered saline (pbs) at ph 7.4. doxorubicin (dox), an anthracycline anticancer drug, was loaded into nanoparticles as a model anticancer drug. the in vitro release results showed that the release behaviors could be altered by adjusting the composition of the comb copolymer and ph of the release medium. in vitro methyl thiazolyl tetrazolium (mtt) assays demonstrated that the copolymers were biocompatible, and dox-loaded nanoparticles showed effective inhibition of cellular proliferation. hemolysis tests indicated that the copolymers were also hemocompatible, and that the presence of the copolymers could reduce the hemolysis ratio (hr) of the dox significantly. in addition, the comb copolymers could be modified through versatile cu(i)-catalyzed "click chemistry" between the terminal alkyne group and azide-modified functional agents. these properties indicate that the ph-responsive clickable comb copolymers are promising candidates for multifunctional nanocarriers in cancer diagnosis and therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302262000011 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48290]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,He CL,Xiao CS,et al. pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)-grafted comb copolymers[J]. macromolecular research,2012,20(3):292-301. |
| APA | Ding JX,He CL,Xiao CS,Chen J,Zhuang XL,&Chen XS.(2012).pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)-grafted comb copolymers.macromolecular research,20(3),292-301. |
| MLA | Ding JX,et al."pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)-grafted comb copolymers".macromolecular research 20.3(2012):292-301. |
入库方式： OAI收割
来源：长春应用化学研究所
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