Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique
文献类型：期刊论文
| 作者 | Xin Y ; Pi ZF ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | chinese journal of chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 30期号:3页码:656-664 |
| 关键词 | TANDEM MASS-SPECTROMETRY BIOTRANSFORMATION IDENTIFICATION MESACONITINE MECHANISM TOXICITY PLASMA |
| ISSN号 | 1001-604x |
| 通讯作者 | liu sy |
| 中文摘要 | the extract of radix aconiti was incubated with rat intestinal bacteria in vitro. further, aconitine and hypaconitine standard were incubated at the same condition as the extract of radix aconiti, respectively. ultra performance liquid chromatography/multi-mass spectrometry (uplc/msn) was used for detecting and identifying all the aconite alkaloids. results showed that there were four metabolites which were identified as 8-butyryl-14-benzoylmesa-conine (m/z660), 8-propionyl-14-benzoylaconine (m/z660), 8-butyryl-14-benzoylaconine (m/z 674) and 8-valeryl-14-benzoylmesaconine (m/z674) in the metabolized sample of the extract of radix aconiti. the relative area ratio of them presented increasing trend during 6 d. on the basis of all results, we could concluded that substitution at n atom mainly influenced the metabolizing rate of diester-diterpenoid alkaloids (ddas), c-8 substitute was active metabolized site, intestinal bacterial metabolites of the aconite alkaloids in the extract of radix aconiti were mainly the substitute with propionyl group, butyl group or valeryl group at c-8. this paper illustrated holistic metabolizing profile of the extract of radix aconiti in vitro and possible metabolizing reaction type of main ddas, which could provide reference for finding out potential bioactive components in the extract and the prescription of chinese medicine. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301541600030 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48293]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xin Y,Pi ZF,Song FR,et al. Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique[J]. chinese journal of chemistry,2012,30(3):656-664. |
| APA | Xin Y,Pi ZF,Song FR,Liu ZQ,&Liu SY.(2012).Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique.chinese journal of chemistry,30(3),656-664. |
| MLA | Xin Y,et al."Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique".chinese journal of chemistry 30.3(2012):656-664. |
入库方式： OAI收割
来源：长春应用化学研究所
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