Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition
文献类型：期刊论文
| 作者 | Xiao HH ; Zhou DF ; Liu S ; Qi RG ; Zheng YH ; Huang YB ; Jing XB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2012 |
| 卷号 | 12期号:3页码:367-373 |
| 关键词 | IN-VITRO ANTITUMOR-ACTIVITY BLOCK-COPOLYMERS PLATINUM DRUG COMPLEXES CHEMISTRY CISPLATIN MICELLES CARRIERS |
| ISSN号 | 1616-5187 |
| 通讯作者 | jing xb |
| 中文摘要 | a biodegradable and amphiphilic copolymer, mpeg-b-p(la-co-mac/tma) that contains pendant 1,2-bidentate carboxyl groups is synthesized by thiol-ene radical addition and is further used to chelate with the active anticancer species (dach-pt) of oxaliplatin to form an mpeg-b-p(la-co-mac/tma-pt-dach) complex. the polymer platinum complex can self-assemble into micelles. in vitro studies show that the dach-pt micelles display enhanced or comparable cytotoxicity against skov-3 and mcf-7 cancer cells, while they show reduced toxicity to hela cells compared with oxaliplatin. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301052700008 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48299]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao HH,Zhou DF,Liu S,et al. Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition[J]. macromolecular bioscience,2012,12(3):367-373. |
| APA | Xiao HH.,Zhou DF.,Liu S.,Qi RG.,Zheng YH.,...&Jing XB.(2012).Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition.macromolecular bioscience,12(3),367-373. |
| MLA | Xiao HH,et al."Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition".macromolecular bioscience 12.3(2012):367-373. |
入库方式： OAI收割
来源：长春应用化学研究所
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