pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres
文献类型：期刊论文
| 作者 | Dai YL ; Zhang CM ; Cheng ZY ; Ma PA ; Li CX ; Kang XJ ; Yang DM ; Lin J |
| 刊名 | biomaterials
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:8页码:2583-2592 |
| 关键词 | MESOPOROUS SILICA NANOSPHERES INFRARED UP-CONVERSION BIOMEDICAL APPLICATIONS HYDROTHERMAL SYNTHESIS FLUORIDE NANOCRYSTALS HOLLOW SPHERES NANOPARTICLES RELEASE CORE NANOCAPSULES |
| ISSN号 | 0142-9612 |
| 通讯作者 | cheng zy |
| 中文摘要 | in this study, we design a controlled release system based on caf2:ce3+/tb3+-poly(acrylic acid) (paa) composite microspheres, which were fabricated by filling the ph-responsive paa inside caf2:ce3+/tb3+ hollow spheres via photopolymerization route. the caf2:ce3+/tb3+ hollow spheres prepared by hydrothermal route possess mesoporous structure and show strong green fluorescence from tb3+ under uv excitation. doxorubicin hydrochloride (dox), a widely used anti-cancer drug, was used as a model drug to evaluate the loading and controlled release behaviors of the composite microspheres due to the good biocompatibility of the samples using mtt assay. the composite carriers provide a strongly ph-dependent drug release behavior owing to the intrinsic property of paa and its interactions with dox. the endocytosis process of drug-loaded microspheres was observed using confocal laser scanning microscopy (clsm) and the in vitro cytotoxic effect against skov3 ovarian cancer cells of the dox-loaded carriers was investigated. in addition, the extent of drug release could be monitored by the altering of photoluminescence (pl) intensity of caf2:ce3+/tb3+. considering the good biocompatibility, high drug loading content and ph-dependent drug release of the materials, these hybrid luminescent microspheres have potential applications in drug controlled release and disease therapy. (c) 2011 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000300469800015 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48304]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Dai YL,Zhang CM,Cheng ZY,et al. pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres[J]. biomaterials,2012,33(8):2583-2592. |
| APA | Dai YL.,Zhang CM.,Cheng ZY.,Ma PA.,Li CX.,...&Lin J.(2012).pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres.biomaterials,33(8),2583-2592. |
| MLA | Dai YL,et al."pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres".biomaterials 33.8(2012):2583-2592. |
入库方式： OAI收割
来源：长春应用化学研究所
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