Highly sensitive fluorescent detection of trypsin based on BSA-stabilized gold nanoclusters
文献类型：期刊论文
| 作者 | Hu LZ ; Han S ; Parveen S ; Yuan YL ; Zhang L ; Xu GB |
| 刊名 | biosensors & bioelectronics
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:1页码:297-299 |
| 关键词 | AU NANOCLUSTERS PROTEASE ASSAY NANOPARTICLES CLUSTERS PROBE WATER HG2+ |
| ISSN号 | 0956-5663 |
| 通讯作者 | xu gb |
| 中文摘要 | in this study, fluorescent metal nanoclusters are presented as novel probes for sensitive detection of protease for the first time. the sensing mechanism is based on trypsin digestion of the protein template of bsa-stabilized au nanoclusters. the decrease in fluorescence intensity of bsa-au nanoclusters caused by trypsin allows the sensitive detection of trypsin in the range of 0.01-100 mu g/ml. the detection limit for trypsin is 2 ng/ml (86 pm) at a signal-to-noise ratio of 3. the present nanosensor for trypsin detection possesses red emission, excellent biocompatibility, high selectivity, and good stability. in addition, we demonstrated the application of the present approach in real urine samples, which suggested its potential for diagnostic purposes. (c) 2011 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301011100045 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48323]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu LZ,Han S,Parveen S,et al. Highly sensitive fluorescent detection of trypsin based on BSA-stabilized gold nanoclusters[J]. biosensors & bioelectronics,2012,32(1):297-299. |
| APA | Hu LZ,Han S,Parveen S,Yuan YL,Zhang L,&Xu GB.(2012).Highly sensitive fluorescent detection of trypsin based on BSA-stabilized gold nanoclusters.biosensors & bioelectronics,32(1),297-299. |
| MLA | Hu LZ,et al."Highly sensitive fluorescent detection of trypsin based on BSA-stabilized gold nanoclusters".biosensors & bioelectronics 32.1(2012):297-299. |
入库方式： OAI收割
来源：长春应用化学研究所
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