Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography-tandem mass spectrometry
文献类型：期刊论文
| 作者 | Liu S ; Yan J ; Xing JP ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2012 |
| 卷号 | 59页码:96-101 |
| 关键词 | ANTIINFLUENZA VIRUS ACTIVITY INFLUENZA-VIRUS PLANT FLAVONOIDS SIALIDASE LEAVES REPLICATION METABOLISM INDIRUBIN ALPHA CELLS |
| ISSN号 | 0731-7085 |
| 通讯作者 | liu zq |
| 中文摘要 | the liquid chromatography-tandem mass spectrometry (lc-ms/ms) methods were used to identify the pharmacologically active n-butanol extract from compound indigowoad root granule. as a result, eighteen compounds belonging to various structural classes such as nucleosides, purines, flavonoids and amino acid were unambiguously identified. then an in vitro neuraminidase (na) inhibition assay was carried out to examine the inhibitory activity of the standard samples and extracts on na. after which, ultrafiltration liquid chromatography with photodiode array detection coupled to electrospray ionization tandem mass spectrometry (ultrafiltration lc-ms/ms) was used to study na inhibitory activity of standard flavones and n-butanol extract of compound indigowoad root granule. this method is highly selective and sensitive, and it could be used for characterization of bioactive compounds and botanical extracts. the result provides some enlightenment for the explanation of the antiviral activity of compound lndigowoad root granule and some guidance for natural anti-influenza medicine development. (c) 2011 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000297716500013 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48336]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu S,Yan J,Xing JP,et al. Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography-tandem mass spectrometry[J]. journal of pharmaceutical and biomedical analysis,2012,59:96-101. |
| APA | Liu S,Yan J,Xing JP,Song FR,Liu ZQ,&Liu SY.(2012).Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography-tandem mass spectrometry.journal of pharmaceutical and biomedical analysis,59,96-101. |
| MLA | Liu S,et al."Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography-tandem mass spectrometry".journal of pharmaceutical and biomedical analysis 59(2012):96-101. |
入库方式： OAI收割
来源：长春应用化学研究所
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