Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection
文献类型：期刊论文
| 作者 | Zhu DR ; Li X ; Sun JY ; You TY |
| 刊名 | talanta
 |
| 出版日期 | 2012 |
| 卷号 | 88页码:265-271 |
| 关键词 | RESPONSE-SURFACE METHODOLOGY TANDEM MASS-SPECTROMETRY SOLID-PHASE EXTRACTION EXPERIMENTAL-DESIGNS HUMAN PLASMA DIETARY-SUPPLEMENTS HUMAN SERUM DIPHENHYDRAMINE CHROMATOGRAPHY CHLORPHENIRAMINE |
| ISSN号 | 0039-9140 |
| 通讯作者 | you ty |
| 中文摘要 | this work expanded the knowledge of the use of chemometric experimental design in optimizing of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection. specially, central composite design was employed for optimizing the three critical electrophoretic variables (tris-h3po4 buffer concentration, buffer ph value and separation voltage) using the chromatography resolution statistic function (crs function) as the response variable. the optimum conditions were established from empirical model: 24.2 mm tris-h3po4 buffer (ph 2.7) with separation voltage of 15.9 kv. applying theses conditions, the six antihistamines (carbinoxamine, chlorpheniramine, cyproheptadine, doxylamine, diphenhydramine and ephedrine) could be simultaneous separated in less than 22 min. our results indicate that the chemometrics optimization method can greatly simplify the optimization procedure for multi-component analysis. the proposed method was also validated for linearity, repeatability and sensitivity, and was successfully applied to determine these antihistamine drugs in urine. (c) 2011 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000301159400034 |
| 公开日期 | 2013-06-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48383]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhu DR,Li X,Sun JY,et al. Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection[J]. talanta,2012,88:265-271. |
| APA | Zhu DR,Li X,Sun JY,&You TY.(2012).Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.talanta,88,265-271. |
| MLA | Zhu DR,et al."Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection".talanta 88(2012):265-271. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。