Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma
文献类型：期刊论文
| 作者 | Lu TC ; Jing XB ; Song XF ; Wang XR |
| 刊名 | journal of applied polymer science
 |
| 出版日期 | 2012 |
| 卷号 | 123期号:1页码:209-217 |
| 关键词 | MULTIFUNCTIONAL MICELLES ANTICANCER DRUG TUMOR-CELLS ADRIAMYCIN INHIBITION FAS/APO-1 |
| ISSN号 | 0021-8995 |
| 通讯作者 | lu tc |
| 中文摘要 | the purpose of this study was to evaluate both cytotoxicity in vitro and in vivo anticancer activities of implantable doxorubicin hydrocloride (dox)-loaded diblock copolymer poly(ethylene glycol)-b-poly(l-lactic acid) (peg-pla) fiber mats (hereafter medicated mats). for in vitro evaluation, smmc7721 cells were directly exposed to the medicated fiber mats, followed with mtt assay. for in vivo evaluation, the medicated mats were locally implanted into h22 tumor-bearing mice, followed with detection of fas protein and flow cytometry analysis. the results showed that in vitro cytotoxicity of medicated fibers were sustained throughout the whole experiment process with the degradation of fiber matrix, while that of pure dox was reduced in six days; medicated fibers had superior in vivo anticancer activities to pure dox (p < 0.01). in conclusion, doxorubicin-loaded peg-pla electrospun fiber mats had the properties of loading doxorubicin hydrochloride (dox) and sustained release of dox from medicated fiber matrix and apparently retained both in vitro cytotoxicity and in vivo anticancer activities in a long term. medicated fiber mats are therefore suitable for a local therapy device. (c) 2011 wiley periodicals, inc. j appl polym sci 123: 209-217, 2012 |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000296437600023 |
| 公开日期 | 2013-06-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48407]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lu TC,Jing XB,Song XF,et al. Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma[J]. journal of applied polymer science,2012,123(1):209-217. |
| APA | Lu TC,Jing XB,Song XF,&Wang XR.(2012).Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma.journal of applied polymer science,123(1),209-217. |
| MLA | Lu TC,et al."Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma".journal of applied polymer science 123.1(2012):209-217. |
入库方式： OAI收割
来源：长春应用化学研究所
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