Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents
文献类型：期刊论文
| 作者 | Geng, Chang-An ; Wang, Li-Jun; Guo, Rui-Hua; Chen, Ji-Jun
|
| 刊名 | MINI-REVIEWS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 13期号:5页码:749-776 |
| 关键词 | Hepatitis B virus (HBV) small-molecule inhibitors nucleoside analogs non-nucleosides natural products synthesized compounds chemical modification patents |
| ISSN号 | 1389-5575 |
| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; chenjj@mail.kib.ac.cn |
| 英文摘要 | Hepatitis B virus (HBV) infection is a serious health problem worldwide, and the current treatment methods including vaccines, immunomodulators, interferons and nucleoside analogs are far from satisfactory. For the search of new anti-HBV agents, much investigation has revealed a large number of small-molecule compounds with various skeletons and promising anti-HBV activities. Although some reviews on anti-HBV progress have been published, they are mainly concentrated on the results reported in journal articles. This review provides an overview of the structural features and anti-HBV properties of the small-molecule anti-HBV inhibitors claimed in recent patents (from 2001 to 2010). These small-molecules can be structurally classified as two main types, nucleoside analogs (cyclic and acyclic nucleosides) and non-nucleosides (natural and synthesized compounds), which are declared with the activity inhibiting the secretion of HBsAg and HBeAg and HBV DNA replication in vitro, as well as anti-DHBV DNA in vivo. Especially, the non-nucleosides with diverse skeletons and novel mechanism offer prolific candidates for anti-HBV drug discovery, which are preferred to be used as adjuvant therapy for HBV infection. This paper will provide valuable information for understanding the current anti-HBV investigation and developing new anti-HBV agents. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | INFECTION ; CCCDNA ; HBV ; REPLICATION ; PERSISTENCE ; PREVENTION ; NUCLEOSIDE ; ANALOGS ; DESIGN |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China [81025023]; National Natural Science Foundation of China [U0832603, 81202436]; National Natural Science Foundation of Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science [F/5202-1] |
| 语种 | 英语 |
| WOS记录号 | WOS:000317271100012 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16413]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,et al. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2013,13(5):749-776. |
| APA | Geng, Chang-An,Wang, Li-Jun,Guo, Rui-Hua,&Chen, Ji-Jun.(2013).Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents.MINI-REVIEWS IN MEDICINAL CHEMISTRY,13(5),749-776. |
| MLA | Geng, Chang-An,et al."Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents".MINI-REVIEWS IN MEDICINAL CHEMISTRY 13.5(2013):749-776. |
入库方式： OAI收割
来源：昆明植物研究所
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