Anti-HBV active constituents from Piper longum
文献类型：期刊论文
| 作者 | Jiang, Zhi-Yong; Liu, Wen-Feng; Zhang, Xue-Mei ; Luo, Jie; Ma, Yun-Bao; Chen, Ji-Jun
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 23期号:7页码:2123-2127 |
| 关键词 | Piper longum Longumoside Amide alkaloids Anti-HBV activity |
| ISSN号 | 0960-894X |
| 通讯作者 | Jiang, ZY (reprint author), State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China. ; jiangzy2010@163.com ; chenjj@mail.kib.ac.cn |
| 英文摘要 | In the screening search for Hepatitis B virus inhibitory agents from medicinal plants, the ethanol extract of Piper longum Linn. was found to possess superior anti-HBV activity in vitro. Bioassay-guided fractionation coupled with repeated purification resulted in the isolation of four new compounds, involving two new glycosides longumosides A (1) and B (2) and two new amide alkaloids erythro-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (3), threo-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (4), as well as two compounds 3 beta,4 alpha-dihydroxy-2-piperidinone (5), 5,6-dihydro-2(1H)-pyridinone (6) from natural source for the first time. The structures of the four new compounds were determined by extensive analyses of the MS, IR, 1D and 2D NMR data. Besides, the compounds 2-6, together with the known compounds 7-11 obtained previously, were assayed for their anti-HBV activity by using Hep G 2.2.15 cell line in vitro. Results suggested the compound piperine (7) possessed remarkable inhibitory HBV activity, against the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with the Selectivity Index (SI) values of 15.7 and 16.8, respectively. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | FRUITS ; INHIBITION ; AMIDES |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China (NSFC) [21162041]; Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission 82 Ministry of Education, Yunnan University of Nationalities [11HXYJS05] |
| 语种 | 英语 |
| WOS记录号 | WOS:000316642900042 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16435]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,et al. Anti-HBV active constituents from Piper longum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(7):2123-2127. |
| APA | Jiang, Zhi-Yong,Liu, Wen-Feng,Zhang, Xue-Mei,Luo, Jie,Ma, Yun-Bao,&Chen, Ji-Jun.(2013).Anti-HBV active constituents from Piper longum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(7),2123-2127. |
| MLA | Jiang, Zhi-Yong,et al."Anti-HBV active constituents from Piper longum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.7(2013):2123-2127. |
入库方式： OAI收割
来源：昆明植物研究所
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