Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
文献类型：期刊论文
| 作者 | Wan, Qin-Li1,2; Zheng, Shan-Qing1,2; Wu, Gui-Sheng3,4 ; Luo, Huai-Rong1
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| 刊名 | EXPERIMENTAL GERONTOLOGY
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| 出版日期 | 2013-05-01 |
| 卷号 | 48期号:5页码:499-506 |
| 关键词 | Caenorhabditis elegans Aspirin Lifespan AMPK DAF-16/FOXO Dietary restriction |
| ISSN号 | 0531-5565 |
| 通讯作者 | Luo, HR (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 134 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China. ; luohuairong@mail.kib.ac.cn |
| 英文摘要 | Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Geriatrics & Gerontology |
| 类目[WOS] | Geriatrics & Gerontology |
| 研究领域[WOS] | Geriatrics & Gerontology |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; C-ELEGANS ; CALORIE RESTRICTION ; GENETIC PATHWAYS ; OXIDATIVE STRESS ; LONGEVITY ; COLON ; METABOLISM ; DISEASE |
| 收录类别 | SCI |
| 资助信息 | Yunnan provincial government [20080A007]; Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P20080-ZZ21, T20090-KF05] |
| 语种 | 英语 |
| WOS记录号 | WOS:000317182600007 |
| 公开日期 | 2013-06-08 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16451]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506. |
| APA | Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,&Luo, Huai-Rong.(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499-506. |
| MLA | Wan, Qin-Li,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499-506. |
入库方式： OAI收割
来源：昆明植物研究所
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