Construction of glycoprotein multilayers using the layer-by-layer assembly technique
文献类型：期刊论文
| 作者 | Wang B ; Liu ZY ; Xu YL ; Li YH ; An TZ ; Su ZH ; Peng B ; Lin Y ; Wang Q |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:34页码:17954-17960 |
| 关键词 | QUARTZ-CRYSTAL MICROBALANCE CELL-ADHESION QCM-D CARCINOEMBRYONIC ANTIGEN RECOGNITION FILMS SURFACES GOLD HYDROXYAPATITE CONFORMATION |
| ISSN号 | 0959-9428 |
| 通讯作者 | an tz |
| 中文摘要 | a novel glycoprotein film was assembled from pig gastric mucin and poly(acrylamide-co-3-acrylamidophenylboronic acid) using a layer-by-layer technique, driven by the formation of boronate ester bonds between the boronic acid units and the polyols. the assembly was monitored by quartz crystal microbalance and uv-vis spectroscopy. the film thickness is increased with increasing the ionic strength and the ph of assembly solutions. furthermore, the dynamic response of the assembled film to the presence of glucose was monitored in real time using quartz crystal microbalance with dissipation. glucose competes with pig gastric mucin to bind with the boronic acid units in the multilayer film, resulting in its disassembly, and the disassembly rate is a function of the glucose concentration. the film is also sensitive to glucose at physiological conditions, albeit the response is weaker and slower than that at higher ph. this glucose-sensitive glycoprotein multilayer film can therefore be applied in glucose sensing and self-regulated insulin release systems. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000307305700079 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48497]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang B,Liu ZY,Xu YL,et al. Construction of glycoprotein multilayers using the layer-by-layer assembly technique[J]. journal of materials chemistry,2012,22(34):17954-17960. |
| APA | Wang B.,Liu ZY.,Xu YL.,Li YH.,An TZ.,...&Wang Q.(2012).Construction of glycoprotein multilayers using the layer-by-layer assembly technique.journal of materials chemistry,22(34),17954-17960. |
| MLA | Wang B,et al."Construction of glycoprotein multilayers using the layer-by-layer assembly technique".journal of materials chemistry 22.34(2012):17954-17960. |
入库方式： OAI收割
来源：长春应用化学研究所
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