Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release
文献类型：期刊论文
| 作者 | Shi FH ; Ding JX ; Xiao CS ; Zhuang XL ; He CL ; Chen L ; Chen XS |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:28页码:14168-14179 |
| 关键词 | DRUG-DELIVERY POLY(L-GLUTAMIC ACID) GENE DELIVERY CANCER-CELLS PH CARRIERS THERAPY COPOLYMERS POLYMERS |
| ISSN号 | 0959-9428 |
| 通讯作者 | zhuang xl |
| 中文摘要 | two kinds of reduction and ph responsive disulfide-cross-linked poly(ethylene glycol)-polypeptide copolymers were prepared through one-step ring-opening polymerization of gamma-benzyl-l-glutamate n-carboxyanhydride (blg nca) or epsilon-benzyloxycarbonyl-l-lysine n-carboxyanhydride (zll nca) and l-cystine n-carboxyanhydride (lc nca) with amino group terminated monomethoxy poly(ethylene glycol) (mpeg-nh2) as macroinitiator. then, the copolymers were deprotected and dispersed in phosphate buffered saline, yielding peg-polypeptide nanogels. doxorubicin (dox), a model anticancer drug, was effectively loaded into nanogels via electrostatic and hydrophobic interactions. the dox release from all dox-loaded nanogels was accelerated in intracellular reductive and acidic conditions, which controlled by fickian diffusion and nanogels swelling. the enhanced intracellular dox release was observed in glutathione monoester (gsh-oet) pretreated hela cells. dox-loaded nanogels showed higher cellular proliferation inhibition towards gsh-oet pretreated hela and hepg2 cells than to unpretreated or buthionine sulfoximine (bso) pretreated cells. hemolysis tests indicated that nanogels were hemocompatible, and the presence of nanogels could reduce the hemolysis ratio (hr) of dox significantly. these features suggest that the nanogels can efficiently load and deliver dox into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a favorable platform to construct an efficient drug delivery system for cancer therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305796300045 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48503]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi FH,Ding JX,Xiao CS,et al. Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release[J]. journal of materials chemistry,2012,22(28):14168-14179. |
| APA | Shi FH.,Ding JX.,Xiao CS.,Zhuang XL.,He CL.,...&Chen XS.(2012).Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release.journal of materials chemistry,22(28),14168-14179. |
| MLA | Shi FH,et al."Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release".journal of materials chemistry 22.28(2012):14168-14179. |
入库方式： OAI收割
来源：长春应用化学研究所
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