Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer
文献类型：期刊论文
| 作者 | Wu SH ; Kuang HH ; Meng FB ; Wu YJ ; Li XY ; Jing XB ; Huang YB |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:30页码:15348-15356 |
| 关键词 | DRUG-DELIVERY POLYMERIC MICELLES MULTIFUNCTIONAL COATINGS POLY(ETHYLENE GLYCOL) SHELL NANOSPHERES BLOCK-COPOLYMERS CARBONATE) DOPAMINE LINKING MICELLIZATION |
| ISSN号 | 0959-9428 |
| 通讯作者 | meng fb |
| 中文摘要 | efficient delivery of anti-cancer drugs into tumor cells for enhancing the intracellular drug concentration is a major challenge for cancer therapy due to the instability of drug-loading vehicle. in this report, we developed a simple method to stabilize the nanostructure of micelles only by bubbling air to crosslink the outer layer of the micelle core. dopamine was conjugated to a biodegradable triblock copolymer monomethoxy poly(ethylene glycol)-b-poly(2-methyl-2-carboxyl-propylene carbonate)-b-poly(l-lactide) (mpeg-b-pmcc-b-pla) to obtain dopamine grafted copolymer mpeg-b-p(mcc-g-dopamine)-b-pla. after self-assembly, the core cross-linked micelles were then prepared by the oxidative self-polymerization of dopamine in the middle hydrophobic phase of the micelles. the cross-linked micelles had smaller sizes and narrower particle size distributions than their uncross-linked precursors. the improved stability was confirmed by critical micelle concentration (cmc) experiments and h-1 nmr spectra. the kinetics and processes of oxidative cross-linking of micelles under air flux were monitored by uv-vis spectroscopy and transmission electron microscopy (tem). these core cross-linked micelles were able to load doxorubicin (dox) with superior loading capacity of up to 19.5% (w/w, drug/micelle) with high drug loading efficiency (97.5%). compared with the uncross-linked ones, drug release efficacy from the cross-linked micelles extremely decreased at ph 7.4. however, a properly sustained release occurred at ph 5.0, which is very favorable for drug delivery in tumor cells. the dox-loaded micelles had similar cytotoxicity as the free drug and could be effectively internalized into mda-mb-231 cells. this controllable and convenient approach for preparing core cross-linked micelles will have a pragmatic future in stabilizing the architecture of nanocarriers for drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306215900075 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48512]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu SH,Kuang HH,Meng FB,et al. Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer[J]. journal of materials chemistry,2012,22(30):15348-15356. |
| APA | Wu SH.,Kuang HH.,Meng FB.,Wu YJ.,Li XY.,...&Huang YB.(2012).Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer.journal of materials chemistry,22(30),15348-15356. |
| MLA | Wu SH,et al."Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer".journal of materials chemistry 22.30(2012):15348-15356. |
入库方式： OAI收割
来源：长春应用化学研究所
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