Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line
文献类型：期刊论文
| 作者 | Wu WB ; Zheng YH ; Wang R ; Huang WL ; Liu L ; Hu XL ; Liu S ; Yue J ; Tong T ; Jing XB |
| 刊名 | international journal of nanomedicine
 |
| 出版日期 | 2012 |
| 卷号 | 7页码:3487-3502 |
| 关键词 | PHASE-II TRIAL IN-VITRO BLOCK-COPOLYMER CASPASE-3 EXPRESSION RADIATION-THERAPY UP-REGULATION CARCINOMA CHEMORADIOTHERAPY APOPTOSIS BAX |
| ISSN号 | 1178-2013 |
| 通讯作者 | tong t |
| 中文摘要 | background: esophageal cancer is recognized as one of the most refractory pernicious diseases. in addition, it is an aggressive malignancy with a propensity for local progression and distant dissemination. because of the poor long-term prognosis for patients with esophageal cancer, increasing attention has focused on the integration of targeted agents into current therapeutics. nevertheless, there have been few studies reported concerning the therapeutic efficacy of paclitaxel-conjugated polymeric micelles in human esophageal cancer in vivo. therefore, the aim of this research was to investigate the tumor inhibition effect of composite micelles containing folic acid and paclitaxel on the human esophageal ec9706 cancer cell line. methods and results: intravenous administration of folate-targeted, paclitaxel-loaded micelles was demonstrated to be more efficient in inhibiting subcutaneous xenograft tumors and extending the survival rate of tumor-bearing nude mice than free paclitaxel and plain paclitaxel micelles at an equivalent paclitaxel dose of 20 mg/kg, which was further backed up by flow cytometry, tunel, and expression of apoptosis-related proteins, including bax, bcl2, and caspase 3 in this study. conclusion: the folate-mediated paclitaxel-loaded polymeric micelle is a promising agent for the treatment of human esophageal cancer. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000306103300001 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48517]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu WB,Zheng YH,Wang R,et al. Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line[J]. international journal of nanomedicine,2012,7:3487-3502. |
| APA | Wu WB.,Zheng YH.,Wang R.,Huang WL.,Liu L.,...&Jing XB.(2012).Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line.international journal of nanomedicine,7,3487-3502. |
| MLA | Wu WB,et al."Antitumor activity of folate-targeted, paclitaxel-loaded polymeric micelles on a human esophageal EC9706 cancer cell line".international journal of nanomedicine 7(2012):3487-3502. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。