Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker
文献类型：期刊论文
| 作者 | Hu XL ; Wang R ; Yue J ; Liu S ; Xie ZG ; Jing XB |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:26页码:13303-13310 |
| 关键词 | AMPHIPHILIC BLOCK-COPOLYMERS HPMA COPOLYMERS DRUG-DELIVERY DESIGN TUMOR FUNCTIONALIZATION MICELLES |
| ISSN号 | 0959-9428 |
| 通讯作者 | jing xb |
| 中文摘要 | multifunctional micelles were successfully prepared by co-assembling a doxorubicin-conjugated copolymer (mpeg-b-p(la-co-me/dox), for antitumor properties) and a rhodamine b-conjugated copolymer (mpeg-b-p(la-co-me/rhb), for imaging) with a folic acid (fa)-conjugated copolymer (fa-peg-b-pla, for targeting), respectively. dls showed that the sizes of these micelles were in the range of 150-300 nm. fluorescent imaging analysis based on the rhb signals of the isolated visceral organs showed that the micelles with or without fa moieties were mainly accumulated in the liver and in the tumor from 2 h post drug administration, maximized at ca. 6 h, and decayed afterwards. more fa-carrying micelles were accumulated in the tumor for a longer time compared to the micelles without fa moieties. dox-containing micelles were used for tumor inhibition experiments in vivo and the results showed that the micelles with fa moieties exhibited better antitumor efficacy than those without fa and free dox. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305242300047 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48532]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu XL,Wang R,Yue J,et al. Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker[J]. journal of materials chemistry,2012,22(26):13303-13310. |
| APA | Hu XL,Wang R,Yue J,Liu S,Xie ZG,&Jing XB.(2012).Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker.journal of materials chemistry,22(26),13303-13310. |
| MLA | Hu XL,et al."Targeting and anti-tumor effect of folic acid-labeled polymer-Doxorubicin conjugates with pH-sensitive hydrazone linker".journal of materials chemistry 22.26(2012):13303-13310. |
入库方式： OAI收割
来源：长春应用化学研究所
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