Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH
文献类型：期刊论文
| 作者 | Zhao L ; Ding JX ; Xiao CS ; He P ; Tang ZH ; Pang X ; Zhuang XL ; Chen XS |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:24页码:12319-12328 |
| 关键词 | RESPONSIVE CONTROLLED-RELEASE DRUG-DELIVERY IN-VIVO POLY(L-GLUTAMIC ACID) SYSTEM COPOLYMERS POLYMERIZATION MICROGELS NANOGELS VITRO |
| ISSN号 | 0959-9428 |
| 通讯作者 | chen xs |
| 中文摘要 | three novel phenylboronic acid functionalized block copolymers, monomethoxy poly(ethylene glycol)b-poly(l-glutamic acid-co-n-3-l-glutamylamidophenylboronic acid) (mpeg-b-p(ga-co-gpba)), were synthesized by modifying mpeg-b-pga with 3-aminophenylboronic acid (apba). the resultant diblock copolymers self-assembled into micelles in phosphate buffer at physiological ph (ph 7.4). more interestingly, at ph 7.4, the hydrodynamic radii (r-h) of the micelles increased with an increase in glucose concentration by formation of hydrophilic pba-glucose complex. thus, insulin, a model drug, was loaded into the glucose-sensitive polypeptide micelles. the in vitro release profiles revealed that the release of insulin from the micelles could be triggered by glucose, i.e. less insulin was released under healthy blood glucose level (1 mg ml(-1) glucose), while quick release occurred under diabetic blood glucose level (above 2 mg ml(-1) glucose). furthermore, in vitro methyl thiazolyl tetrazolium (mtt) assays and hemolysis tests suggested that the copolymers had good biocompatibility. therefore, the phenylboronic acid functionalized block copolymers with high glucose-sensitivity and good biocompatibility may have potential as self-regulated insulin release systems. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000304561900063 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48549]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao L,Ding JX,Xiao CS,et al. Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH[J]. journal of materials chemistry,2012,22(24):12319-12328. |
| APA | Zhao L.,Ding JX.,Xiao CS.,He P.,Tang ZH.,...&Chen XS.(2012).Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH.journal of materials chemistry,22(24),12319-12328. |
| MLA | Zhao L,et al."Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH".journal of materials chemistry 22.24(2012):12319-12328. |
入库方式： OAI收割
来源：长春应用化学研究所
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