Photo-cross-linked mPEG-poly(gamma-cinnamyl-L-glutamate) micelles as stable drug carriers
文献类型：期刊论文
| 作者 | Yan LS ; Yang LX ; He HY ; Hu XL ; Xie ZG ; Huang YB ; Jing XB |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:5页码:1300-1307 |
| 关键词 | BLOCK-COPOLYMER MICELLES RING-OPENING POLYMERIZATION ABC TRIBLOCK COPOLYMERS N-CARBOXYANHYDRIDES POLYPEPTIDES DELIVERY NANOPARTICLES GLYCOPOLYPEPTIDES NANOSPHERES CHEMISTRY |
| ISSN号 | 1759-9954 |
| 通讯作者 | jing xb |
| 中文摘要 | a functionalized l-glutamate n-carboxyanhydride monomer containing a cinnamyl moiety, gamma-cinnamyl-l-glutamate n-carboxyanhydride (clg-nca), was prepared. ring-opening polymerization (rop) of clg-nca initiated by n-hexylamine and amino-terminated poly(ethylene glycol) (mpeg-nh2) was successfully performed with controlled polymer molecular weight and molecular weight distribution. the structures of the obtained monomer and polymers were confirmed by h-1 nmr, c-13 nmr and ftir. the block copolymer mpeg-b-pclg could self-assemble into micelles in aqueous solution which consist of a hydrophobic pclg core and a hydrophilic mpeg shell. under uv-irradiation at 254 nm, the photo-cross-linking process of the cinnamyl-carrying block copolymer micelles was tracked by uv-vis spectra, h-1 nmr, dynamic light scattering (dls) and transmission electron microscopy (tem). in vitro mtt assay demonstrated that the micelles were biocompatible to l929 cells. paclitaxel was loaded into the micelles as a model drug. the in vitro paclitaxel release behaviors indicated that cross-linking of the micelle cores results in a slow drug release in comparison with the non-cross-linked micelles. these results indicated that the photo cross-linked mpeg-b-pclg micelles can be used as drug carriers for intelligent drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302315800026 |
| 公开日期 | 2013-06-30 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48591]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yan LS,Yang LX,He HY,et al. Photo-cross-linked mPEG-poly(gamma-cinnamyl-L-glutamate) micelles as stable drug carriers[J]. polymer chemistry,2012,3(5):1300-1307. |
| APA | Yan LS.,Yang LX.,He HY.,Hu XL.,Xie ZG.,...&Jing XB.(2012).Photo-cross-linked mPEG-poly(gamma-cinnamyl-L-glutamate) micelles as stable drug carriers.polymer chemistry,3(5),1300-1307. |
| MLA | Yan LS,et al."Photo-cross-linked mPEG-poly(gamma-cinnamyl-L-glutamate) micelles as stable drug carriers".polymer chemistry 3.5(2012):1300-1307. |
入库方式： OAI收割
来源：长春应用化学研究所
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