Age-related changes in prostate zonal volumes as measured by high-resolution magnetic resonance imaging (MRI): a cross-sectional study in over 500 patients
文献类型：期刊论文
| 作者 | Turkbey, Baris1; Huang, Robert1; Vourganti, Srinivas2; Trivedi, Hari2; Bernardo, Marcelino1; Yan, Pingkun3; Benjamin, Compton2; Pinto, Peter A.2; Choyke, Peter L.1 |
| 刊名 | bju international
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 110期号:11页码:1642-1647 |
| 关键词 | BPH MRI prostate zonal volumes age-related changes |
| ISSN号 | 1464-4096 |
| 产权排序 | 3 |
| 合作状况 | 国际 |
| 英文摘要 | objective to use ability of magnetic resonance imaging (mri) to investigate age-related changes in zonal prostate volumes. patients and methods this institutional review board approved, health insurance portability and accountability act-compliant study consisted of 503 patients who underwent 3 t prostate mri before any treatment for prostate cancer. whole prostate (wp) and central gland (cg) volumes were manually contoured on t2-weighted mri using a semi-automated segmentation tool. wp, cg, peripheral zone (pz) volumes were measured for each patient. wp, cg, pz volumes were correlated with age, serum prostate-specific antigen (psa) level, international prostate symptom score (ipss), sexual health inventory for men (shim) scores. results linear regression analysis showed positive correlations between wp, cg volumes and patient age (p < 0.001); there was no correlation between age and pz volume (p= 0.173). there was a positive correlation between wp, cg volumes and serum psa level (p < 0.001), as well as between pz volume and serum psa level (p= 0.002). at logistic regression analysis, ipss positively correlated with wp, cg volumes (p < 0.001). shim positively correlated with wp (p= 0.015) and cg (p= 0.023) volumes. as expected, the ipss of patients with prostate volumes (wp, cg) in first decile for age were significantly lower than those in tenth decile. conclusions prostate mri is able to document age-related changes in prostate zonal volumes. changes in wp and cg volumes correlated inversely with changes in lower urinary tract symptoms. these findings suggest a role for mri in measuring accurate prostate zonal volumes; have interesting implications for study of age-related changes in the prostate. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | urology & nephrology |
| 研究领域[WOS] | urology & nephrology |
| 关键词[WOS] | urinary flow-rates ; longitudinal changes ; natural-history ; hyperplasia ; antigen ; men ; adenocarcinoma ; population ; symptoms ; cohort |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312245900018 |
| 公开日期 | 2013-07-02 |
| 源URL | [http://ir.opt.ac.cn/handle/181661/20848]  |
| 专题 | 西安光学精密机械研究所_光学影像学习与分析中心 |
| 作者单位 | 1.NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA 2.NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA 3.Chinese Acad Sci, Ctr OPT IMagery Anal & Learning OPTIMAL, State Key Lab Transient Opt & Photon, Xian Inst Opt & Precis Mech, Xian, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Turkbey, Baris,Huang, Robert,Vourganti, Srinivas,et al. Age-related changes in prostate zonal volumes as measured by high-resolution magnetic resonance imaging (MRI): a cross-sectional study in over 500 patients[J]. bju international,2012,110(11):1642-1647. |
| APA | Turkbey, Baris.,Huang, Robert.,Vourganti, Srinivas.,Trivedi, Hari.,Bernardo, Marcelino.,...&Choyke, Peter L..(2012).Age-related changes in prostate zonal volumes as measured by high-resolution magnetic resonance imaging (MRI): a cross-sectional study in over 500 patients.bju international,110(11),1642-1647. |
| MLA | Turkbey, Baris,et al."Age-related changes in prostate zonal volumes as measured by high-resolution magnetic resonance imaging (MRI): a cross-sectional study in over 500 patients".bju international 110.11(2012):1642-1647. |
入库方式： OAI收割
来源：西安光学精密机械研究所
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