Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway
文献类型：期刊论文
| 作者 | An, JunXia ; Gao, YaRong ; Wang, Jing ; Zhu, QiYu ; Ma, YuLing ; Wu, Jian ; Sun, Jian ; Tang, YaXiong |
| 刊名 | BIOTECHNOLOGY LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 34期号:10页码:1781-1788 |
| 关键词 | Apoptosis Bax Flavokawain B JNK Lung cancer Survivin |
| ISSN号 | 0141-5492 |
| 产权排序 | 1 |
| 通讯作者 | Sun, J (reprint author), Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4,Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China ; Tang, YaXiong |
| 英文摘要 | Flavokawain B (FKB) possesses strong anti-neoplastic activity against many cancer cells. Here we assessed its antitumor activity and molecular mechanisms in lung cancer H460 cells in vitro. FKB significantly inhibited cell proliferation and caused arrest of the cell cycle G2-M of H460 cells in a dose-dependent manner. FKB also inducted apoptosis, which was associated with cytochrome c release, caspase-7 and caspase-9 activation and Bcl-xL/Bax dys-regulation. FKB significantly down-regulated survivin and XIAP, and the inhibitory effect induced by FKB was greatly attenuated by through over-expression of survivin or Bax(-/-) MEFs. Furthermore, FKB activated the mitogen-activated protein kinases and the JNK inhibitor SP600125 significantly decreased the growth-inhibitory and apoptotic effects of FKB. Together, these results suggest the anti-lung cancer potential of flavokawain B for the prevention and treatment of lung cancer. |
| 学科主题 | Biotechnology & Applied Microbiology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [81173095]; International Cooperation Program of Sichuan, China [2011HH0012]; Major Research plan of the National Natural Science Foundation of China [91013006] |
| 语种 | 英语 |
| WOS记录号 | WOS:000310429800002 |
| 公开日期 | 2013-07-03 |
| 源URL | [http://210.75.237.14/handle/351003/23879]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | An, JunXia,Gao, YaRong,Wang, Jing,et al. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway[J]. BIOTECHNOLOGY LETTERS,2012,34(10):1781-1788. |
| APA | An, JunXia.,Gao, YaRong.,Wang, Jing.,Zhu, QiYu.,Ma, YuLing.,...&Tang, YaXiong.(2012).Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway.BIOTECHNOLOGY LETTERS,34(10),1781-1788. |
| MLA | An, JunXia,et al."Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway".BIOTECHNOLOGY LETTERS 34.10(2012):1781-1788. |
入库方式： OAI收割
来源：成都生物研究所
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