Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19)
文献类型：期刊论文
| 作者 | Lu, Dan-feng ; Yang, Li-juan ; Wang, Fei ; Zhang, Guo-lin |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 60期号:34页码:8411-8418 |
| 关键词 | luteolin aromatase estrogen granulosa cell |
| ISSN号 | 0021-8561 |
| 产权排序 | 1 |
| 通讯作者 | Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China ; Zhang, Guo-lin |
| 英文摘要 | Inhibition of aromatase, the key enzyme in estrogen biosynthesis, is an important strategy in the treatment of breast cancer. Several dietary flavonoids show aromatase inhibitory activity, but their tissue specificity and mechanism remain unclear. This study found that the dietary flavonoid luteolin potently inhibited estrogen biosynthesis in a dose- and time-dependent manner in KGN cells derived from human ovarian granulosa Cells, the major source of estrogens in premenopausal, women. Luteolin decreased aromatase mRNA and protein expression in KGN cells. Luteolin also promoted. aromatase protein degradation and inhibited estrogen biosynthesis in aromatase-expressing HEK293A cells, but had no effect on :recombinant: expressed aromatase. Estrogen biosynthesis in KGN cells was inhibited with differing potencies by extracts of onion and bird chili and by four other-dietary flavonoids: kaempferol, quercetin, myricetin, and isorhamnetin. The present study suggests that luteolin inhibits estrogen biosynthesis by decreasing aromatase expression and destabilizing aromatase protein, and it warrants further investigation as a potential treatment for estrogen-dependent cancers. |
| 学科主题 | Agriculture; Chemistry; Food Science & Technology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [20932007, 30900769]; West Light Foundation of the Chinese Academy of Sciences; National New Drug Innovation Major Project of China [2011ZX09307-002-02] |
| 语种 | 英语 |
| WOS记录号 | WOS:000308042800021 |
| 公开日期 | 2013-07-03 |
| 源URL | [http://210.75.237.14/handle/351003/23884]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Lu, Dan-feng,Yang, Li-juan,Wang, Fei,et al. Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(34):8411-8418. |
| APA | Lu, Dan-feng,Yang, Li-juan,Wang, Fei,&Zhang, Guo-lin.(2012).Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(34),8411-8418. |
| MLA | Lu, Dan-feng,et al."Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.34(2012):8411-8418. |
入库方式： OAI收割
来源：成都生物研究所
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