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Toxicity of raw and processed roots of Polygonum multiflorum
文献类型：期刊论文
| 作者 | Wu, Xiaoqing ; Chen, Xiaozhen ; Huang, Qingchun ; Fang, Dongmei ; Li, Guoyou ; Zhang, Guolin |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2012 |
| 卷号 | 83期号:3页码:469-475 |
| 关键词 | Polygonum multiflorum He-Shou-Wu Processing Stilbene Emodin Hepatotoxicity |
| ISSN号 | 0367-326X |
| 产权排序 | 1 |
| 通讯作者 | Zhang, GL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China. |
| 英文摘要 | The roots of Polygonum multillorum (Chinese name: He-Shou-Wu. HSW) are used in traditional Chinese medicine for many diseases in processed form or raw state. There are reports dealing with the toxicity of HSW. However, the toxicity is caused by over dosage or by the herb itself remains unclear. We evaluated the toxicity of raw and processed HSW on Kunming (KM) mice. For raw HSW, the toxicity of water decocta is much higher than that of acetone extract. Meanwhile, the toxicity of acetone extract of raw HSW is considerably higher than that of acetone extract of processed HSW. HPLC analyses revealed that the contents of characteristic compounds in raw HSW were changed after processing: the content of 2.3.4'.5-tetrahydroxystilbene 2-O-beta-D-glucoside was decreased by 55.8%, whereas the content of emodin was increased by 34.0%. Thus, processing could reduce the toxicity of HSW. Thus, the toxicity of HSW does not depend on the content of anthranoid derivatives, it may be correlated with the content of tetrahydroxystilbene glucosides. (C) 2011 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China (973 Program) [2009CB522804] |
| 语种 | 英语 |
| WOS记录号 | WOS:000302109400005 |
| 公开日期 | 2013-07-03 |
| 源URL | [http://210.75.237.14/handle/351003/23903]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Wu, Xiaoqing,Chen, Xiaozhen,Huang, Qingchun,et al. Toxicity of raw and processed roots of Polygonum multiflorum[J]. FITOTERAPIA,2012,83(3):469-475. |
| APA | Wu, Xiaoqing,Chen, Xiaozhen,Huang, Qingchun,Fang, Dongmei,Li, Guoyou,&Zhang, Guolin.(2012).Toxicity of raw and processed roots of Polygonum multiflorum.FITOTERAPIA,83(3),469-475. |
| MLA | Wu, Xiaoqing,et al."Toxicity of raw and processed roots of Polygonum multiflorum".FITOTERAPIA 83.3(2012):469-475. |
入库方式： OAI收割
来源：成都生物研究所
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