Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
文献类型：期刊论文
| 作者 | Wang, Xue-Quan1; Liu, Lan-Xiang1; Li, Yan2 ; Sun, Cheng-Jun1; Chen, Wen1; Li, Liang1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 62页码:111-121 |
| 关键词 | Hybrid compound 2-Benzylbenzofuran Imidazole Cytotoxic activities Structure-activity relationships |
| ISSN号 | 0223-5234 |
| 通讯作者 | Yang, XD (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; xdyang@ynu.edu.cn |
| 英文摘要 | A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Chemistry, Medicinal |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | CYTOTOXIC ACTIVITIES ; DERIVATIVES ; ANALOGS ; DISCOVERY ; SALTS |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China [30960460, 20925205, 21062026]; Natural Science Foundation of Yunnan Province [2010GA014, 2012FB113]; National Basic Research Program of China (973 Program) [2009CB522300] |
| 语种 | 英语 |
| WOS记录号 | WOS:000318577500012 |
| 公开日期 | 2013-07-24 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16577]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xue-Quan,Liu, Lan-Xiang,Li, Yan,et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,62:111-121. |
| APA | Wang, Xue-Quan.,Liu, Lan-Xiang.,Li, Yan.,Sun, Cheng-Jun.,Chen, Wen.,...&Yang, Xiao-Dong.(2013).Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,62,111-121. |
| MLA | Wang, Xue-Quan,et al."Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 62(2013):111-121. |
入库方式： OAI收割
来源：昆明植物研究所
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