Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells
文献类型：期刊论文
| 作者 | Zhao Zhi-fang1; Zhou Li-li1; Chen Xia1; Cheng Yong-xian2; Hou Fan-fan1; Nie Jing1 |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2013-04-05 |
| 卷号 | 126期号:7页码:1230-1235 |
| 关键词 | acortatarin A high glucose mesangial cells extracellular matrix |
| ISSN号 | 0366-6999 |
| 通讯作者 | Nie, J (reprint author), Nanfang Hosp, Div Nephrol, Guangzhou 510515, Guangdong, Peoples R China. ; jingnie2006@163.com |
| 英文摘要 | Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Various treatment regimens and combinations of therapies provide only partial renoprotection. Therefore new approaches are needed to retard the progression of DN. The aim of the present study was to evaluate the role of a novel spiroalkaloid from Acorus tatarinowii named acortatarin A (AcorA) in inhibiting high glucose-induced extracellular matrix accumulation in mesangial cells (MCs). |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Medicine, General & Internal |
| 类目[WOS] | Medicine, General & Internal |
| 研究领域[WOS] | General & Internal Medicine |
| 关键词[WOS] | PROTEIN-KINASE-C ; DIABETIC-NEPHROPATHY ; NADPH OXIDASE ; ACORUS-TATARINOWII ; UP-REGULATION ; EXPRESSION ; ACTIVATION ; MECHANISMS ; COLLAGEN ; KIDNEY |
| 收录类别 | SCI |
| 资助信息 | National "973" Program [2012CB517700]; National Natural Science Foundation of China [U0932002]; Knowledge Innovation Program of Chinese Academy of Sciences [KSCX2-YW-R-211]; Project of Natural Compound Library Construction from Chinese Academy of Sciences [KSCX2-EW-R-15] |
| 语种 | 英语 |
| WOS记录号 | WOS:000319783800006 |
| 公开日期 | 2013-07-24 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16579]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Southern Med Univ, Res Inst Nephrol Guangdong Prov, Key Lab Organ Failure Res, Div Nephrol,Nanfang Hosp,Minist Educ, Guangzhou 510515, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Zhi-fang,Zhou Li-li,Chen Xia,et al. Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells[J]. CHINESE MEDICAL JOURNAL,2013,126(7):1230-1235. |
| APA | Zhao Zhi-fang,Zhou Li-li,Chen Xia,Cheng Yong-xian,Hou Fan-fan,&Nie Jing.(2013).Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells.CHINESE MEDICAL JOURNAL,126(7),1230-1235. |
| MLA | Zhao Zhi-fang,et al."Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells".CHINESE MEDICAL JOURNAL 126.7(2013):1230-1235. |
入库方式： OAI收割
来源：昆明植物研究所
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