Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides
文献类型：期刊论文
| 作者 | Han Wen-Xia; Zhu Hua-Jie |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2013-02-10 |
| 卷号 | 34期号:2页码:346-353 |
| 关键词 | beta-D-Glucoside Phenolic glycoside Anti-HCV activity |
| ISSN号 | 0251-0790 |
| 通讯作者 | Zhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China. ; zhuhuajie@hotmail.com |
| 英文摘要 | Phenolic beta-D-glucopyranosides exist widely in nature and exhibit many important physiological activities. For example, gastrodia isolated from Pholidota chinensis Lind1. has such a sketch and play an important bioactivity on nerve system. Recently, we found another phenolic beta-D-glucopyranoside from the Pulicaria insignis which had definite anti-HCV activity. Based on the results achieved in our research group, we tried to design and synthesize series of phenolic beta-D-glucopyranosides to wish to find new and better bioactive compounds used in anti-HCV study. Fifteen novel natural analogues of phenolic beta-D-glucopyranosides were synthesized from phenolic aglycones and acetobromo-alpha-D-glucose or beta-D-glucose pentaacetate. Their structures were characterized by MS, H-1 NMR and C-13 NMR. Preliminary anti-HCV activity tests showed that compounds 8a and 10a exhibited definite anti-viral activity, their EC50 are 21 and 9.4 mu mol/L, and the CC50 of them are 150.4 and 145.9 mu mol/L, respectively. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | Chemistry, Multidisciplinary |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CURCULIGO-ORCHIOIDES ; O-GLYCOSYLATION ; GLYCOSIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317085400015 |
| 公开日期 | 2013-07-24 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16583]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Reasources West C, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han Wen-Xia,Zhu Hua-Jie. Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2013,34(2):346-353. |
| APA | Han Wen-Xia,&Zhu Hua-Jie.(2013).Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,34(2),346-353. |
| MLA | Han Wen-Xia,et al."Synthesis and Anti-HCV Activity of Analogues of the Natural Phenolic beta-D-Glucopyranosides".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 34.2(2013):346-353. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。