Chemical constituents of Arisaema franchetianum tubers
文献类型：期刊论文
| 作者 | Su, Yao1,2; Xu, Jin-Jin1; Bi, Jun-Long3; Wang, Yue-Hu1 ; Hu, Guang-Wan1; Yang, Jun1; Yin, Ge-Fen3; Long, Chun-Lin1,4
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2013 |
| 卷号 | 15期号:1页码:71-77 |
| 关键词 | Araceae Arisaema franchetianum alkaloids C21 steroids porcine respiratory and reproductive syndrome virus cytotoxicity |
| ISSN号 | 1028-6020 |
| 通讯作者 | Yin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China. ; yingefen383@sohu.com ; long@mail.kib.ac.cn |
| 英文摘要 | A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7]. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | AMURENSE ; ACETATE ; ROOTS ; ASSAY |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China [20972166, 31160509, 31161140345, 31070288]; Yunnan Provincial Program for Excellent Scientists [2009CI125]; Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101] |
| 语种 | 英语 |
| WOS记录号 | WOS:000314452400011 |
| 公开日期 | 2013-07-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/16617]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China 3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Yao,Xu, Jin-Jin,Bi, Jun-Long,et al. Chemical constituents of Arisaema franchetianum tubers[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(1):71-77. |
| APA | Su, Yao.,Xu, Jin-Jin.,Bi, Jun-Long.,Wang, Yue-Hu.,Hu, Guang-Wan.,...&Long, Chun-Lin.(2013).Chemical constituents of Arisaema franchetianum tubers.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(1),71-77. |
| MLA | Su, Yao,et al."Chemical constituents of Arisaema franchetianum tubers".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.1(2013):71-77. |
入库方式： OAI收割
来源：昆明植物研究所
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