Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
文献类型：期刊论文
| 作者 | Zhao QF(赵群飞) ; He QL(贺庆利) ; Ding W(丁伟) ; Tang MC(唐满成) ; Kang QJ(康前进) ; Yu Y(虞沂) ; Deng W(邓玮) ; Zhang Q(张琪) ; Fang J(方洁) ; Tang GL(唐功利) ; Liu W(刘文) |
| 刊名 | Chem. Biol.
 |
| 出版日期 | 2008 |
| 卷号 | 15期号:7页码:693-705 |
| ISSN号 | 1074-5521 |
| 其他题名 | Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis |
| 通讯作者 | 刘文 |
| 英文摘要 | Azinomycin B is a complex natural product containing densely assembled functionalities with potent antitumor activity. Cloning and sequence analysis of the azi gene cluster revealed an iterative type I polyketide synthase (PKS) gene, five nonribosomal peptide synthetases (NRPSs) genes and numerous genes encoding the biosynthesis of unusual building blocks and tailoring steps for azinomycin B production. Characterization of AziB as a 5-methyl-naphthoic acid (NP) synthase showed a distinct selective reduction pattern in aromatic polyketide biosynthesis governed by bacterial iterative type I PKSs. Heterologous expression established the PKS-post modification route from 5-methyl-NPA to reach the first building block 3-methoxy-5-methyl-NPA. This proposed azinomycin B biosynthetic pathway sets the stage to investigate the enzymatic mechanisms for building structurally unique and pharmaceutically important groups, including the unprecedented azabicyclic ring system and highly active epoxide moiety. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.chembiol.2008.05.021 |
| 语种 | 英语 |
| WOS记录号 | WOS:000258019700010 |
| 公开日期 | 2013-08-14 |
| 源URL | [http://202.127.28.38/handle/331003/27713]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Zhao QF,He QL,Ding W,et al. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis[J]. Chem. Biol.,2008,15(7):693-705. |
| APA | 赵群飞.,贺庆利.,丁伟.,唐满成.,康前进.,...&刘文.(2008).Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.Chem. Biol.,15(7),693-705. |
| MLA | 赵群飞,et al."Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis".Chem. Biol. 15.7(2008):693-705. |
入库方式： OAI收割
来源：上海有机化学研究所
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