The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium
文献类型：会议论文
| 作者 | Li AL; Li HW; Jin G(靳刚) ; Xiu RJ
|
| 出版日期 | 2003-02-20 |
| 会议名称 | 5th Asian Congress for Microcirculation, FEB 20-22, 2003 MANILA, PHILIPPINES |
| 通讯作者 | 靳刚 |
| 中文摘要 | This study was designed to observe the effect of tumor conditioned medium (TCM) on the proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). HUVECs were exposed to TCM from breast carcinoma cell line MDA-MB-231, then we measured their proliferation, apoptosis and cell cycle distribution by MTT and flow cytometery (FCM). Following the stimulation of TCM, HUVECs showed higher pro-mitogenic and anti-apoptotic ability than did the negative control group (ECGF-free medium with 20% FBS), but a similar ability to the positive control group (medium with ECGF and 20% FBS). From these results, we can conclude that breast carcinoma cell line MDA-MB-231 could secret soluble pro-angiogenic factors that induce HUVEC angiogenic switching, including cell cycle progression, proliferation and growth. The role and character of these factors remain to be further studied. |
| 收录类别 | CPCI-S |
| 会议录 | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382
 |
| 学科主题 | 力学 |
| 语种 | 英语 |
| WOS记录号 | WOS:000188240800031 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/13896]  |
| 专题 | 力学研究所_力学所知识产出(1956-2008) |
| 推荐引用方式 GB/T 7714 | Li AL,Li HW,Jin G,et al. The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium[C]. 见:5th Asian Congress for Microcirculation, FEB 20-22, 2003 MANILA, PHILIPPINES. |
入库方式： OAI收割
来源：力学研究所
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