Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin
文献类型：期刊论文
| 作者 | Feuerecker M; Feuerecker B; Matzel S; Long M(龙勉) ; Strewe C; Kaufmann I; Hoerl M; Schelling G; Rehm M; Chouker A
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| 刊名 | JOURNAL OF APPLIED PHYSIOLOGY
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 115期号:2页码:235-242 |
| 通讯作者邮箱 | alexander.chouker@med.uni-muenchen.de |
| 关键词 | CD62L shedding immunological changes short-term bed rest |
| ISSN号 | 8750-7587 |
| 产权排序 | [Feuerecker, M.; Feuerecker, B.; Matzel, S.; Strewe, C.; Kaufmann, I.; Hoerl, M.; Schelling, G.; Rehm, M.; Chouker, A.] Univ Munich, Dept Anaesthesiol, Klinikum Grosshadern, D-81377 Munich, Germany; [Long, M.] Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China; [Long, M.] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100080, Peoples R China |
| 通讯作者 | Chouker, A (reprint author), Univ Munich, Dept Anaesthesiol, Marchioninistr 15, D-81377 Munich, Germany. |
| 合作状况 | 国际 |
| 中文摘要 | Head-down-tilt bed rest (HDTBR) is a popular model, simulating alterations of gravitation during space missions. The aim of this study was to obtain a better insight into the complexly orchestrated regulations of HDTBR-induced immunological responses, hypothesizing that artificial gravity can mitigate these HDTBR-related physiological effects. This crossover-designed 5 days of HDTBR study included three protocols with no, or daily 30 min of centrifugation or 6 X 5 min of centrifugation. Twelve healthy, male participants donated blood pre-HDTBR, post-HDTBR, and twice during HDTBR. Cellular immune changes were assessed either by enumerative and immune cell phenotyping assays or by functional testing of responses to either recall antigens or receptor-dependent activation by chemotactic agents N-formyl-methionyl-leucyl-phenylalanine (fMLP) and with TNF-alpha. The expression of the adhesion molecule L-selectin (CD62L) on the surface of granulocytes and its shedding into plasma samples were measured. In parallel, other humoral factor, such as interleukin-6 and interleukin-8, parameters of endothelial damage (glycocalyx) were determined. Hematocrit and hemoglobin were significantly increased during HDTBR. Although immune functional tests did not indicate a change in the immune performance, the expression of CD62L on resting granulocytes was significantly shed by 50% during HDTBR. Although the latter is normally associated to an activation of inflammatory innate immune responses and during interaction of granulocytes with the endothelium, CD62L shedding was, however, not related either to a systemic inflammatory alteration or to shedding of the endothelial glycocalyx during bed rest. This suggests a noninflammatory or "mechanical" shedding related to fluid shifts during head-down intervention and not to an acute inflammatory process. |
| 学科主题 | 交叉与边缘领域的力学 |
| 分类号 | 二类/Q1 |
| 收录类别 | SCI |
| 资助信息 | European Space Agency; German National Space Program [50WB0719/WB0919] |
| 原文出处 | http://dx.doi.org/10.1152/japplphysiol.00381.2013 |
| 语种 | 英语 |
| WOS记录号 | WOS:000321819000012 |
| 公开日期 | 2013-08-21 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/47359]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Feuerecker M,Feuerecker B,Matzel S,et al. Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin[J]. JOURNAL OF APPLIED PHYSIOLOGY,2013,115(2):235-242. |
| APA | Feuerecker M.,Feuerecker B.,Matzel S.,Long M.,Strewe C.,...&Chouker A.(2013).Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin.JOURNAL OF APPLIED PHYSIOLOGY,115(2),235-242. |
| MLA | Feuerecker M,et al."Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin".JOURNAL OF APPLIED PHYSIOLOGY 115.2(2013):235-242. |
入库方式： OAI收割
来源：力学研究所
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