Human telomeric G-quadruplex formation and highly selective fluorescence detection of toxic strontium ions
文献类型：期刊论文
| 作者 | Qu KG ; Zhao CQ ; Ren JS ; Qu XG |
| 刊名 | molecular biosystems
 |
| 出版日期 | 2012 |
| 卷号 | 8期号:3页码:779-782 |
| ISSN号 | 1742-206x |
| 关键词 | CARBON NANOTUBES THIAZOLE ORANGE DRUG DESIGN DNA TARGETS HYDRATION SEQUENCE SR2+ |
| 通讯作者 | qu xg |
| 中文摘要 | strontium ions play important roles in biological systems. the inhalation of strontium can cause severe respiratory difficulties, anaphylactic reaction and extreme tachycardia. strontium can replace calcium in organisms, inhibit normal calcium absorption and induce strontium "rickets" in childhood. thus, the development of sensitive and selective methods for the determination of trace amounts of sr2+ in aqueous media is of considerable importance for environmental and human health protection. a number of methodologies, such as x-ray energy dispersive spectrometry, inductively coupled argon plasma atomic emission spectroscopy (icp-aes), atomic absorption spectrometry (aas) and instrumental thermal neutron activation analysis, have been reported. however, these methods are somewhat complex, costly, time consuming and, especially, need special instruments. thus, the design of convenient and inexpensive approaches for the sensitive and selective detection of sr2+ with rapid, easy manipulation is in ever-increasing demand. to the best of our knowledge, using dna conformational change to detect sr2+ has not yet been reported. herein we utilized thiazole orange (to) as a signal reporter to devise a simple sr2+ detection assay based on sr2+ induced human telomeric dna conformational change in the presence of swnts. the limit of detection is 10 nm sr2+ (0.87 mu g l-1), far below 4 mu g l-1, the u. s. federal threshold in drinking water defined by the u. s. epa. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2013-08-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48665]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Qu KG,Zhao CQ,Ren JS,et al. Human telomeric G-quadruplex formation and highly selective fluorescence detection of toxic strontium ions[J]. molecular biosystems,2012,8(3):779-782. |
| APA | Qu KG,Zhao CQ,Ren JS,&Qu XG.(2012).Human telomeric G-quadruplex formation and highly selective fluorescence detection of toxic strontium ions.molecular biosystems,8(3),779-782. |
| MLA | Qu KG,et al."Human telomeric G-quadruplex formation and highly selective fluorescence detection of toxic strontium ions".molecular biosystems 8.3(2012):779-782. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。