Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates
文献类型：期刊论文
| 作者 | Li M ; Liu Z ; Ren JS ; Qu XG |
| 刊名 | chemical science
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:3页码:868-873 |
| 关键词 | ALZHEIMERS-DISEASE BETA-PEPTIDE CONTROLLED-RELEASE A-BETA TRANSGENIC MICE DRUG-DELIVERY ZINC-BINDING COPPER THERAPY ACETYLCHOLINESTERASE |
| ISSN号 | 2041-6520 |
| 通讯作者 | qu xg |
| 中文摘要 | metal ions play important roles in amyloid aggregation and neurotoxicity. metal-ion chelation therapy has been used in clinical trials for alzheimer's disease (ad) treatment. here we report a novel strategy to design and construct a light controlled-release prochelator by using magnetic nanoparticles as a therapeutic agent for ad. by taking advantage of good biocompatibility, high selectivity toward metal ions of prochelators, and their ability to cross the blood-brain barrier (bbb), the newly synthesized nanoparticle-prochelator conjugates can efficiently inhibit a beta aggregation, decrease cellular reactive oxygen species (ros) and protect cells against a beta-related toxicity, as demonstrated by spectral, tem, gel electrophoresis and cellular toxicity studies. since nanoparticles can cross the blood-brain barrier (bbb) which can overcome the drawbacks of unstable small chemicals or peptides, light-triggered functional nps may provide a new method to construct a beta inhibitors. therefore, our results shed light on the design of controlled-release multifunctional systems for ad treatment. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000299949500031 |
| 公开日期 | 2013-08-29 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/48707]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li M,Liu Z,Ren JS,et al. Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates[J]. chemical science,2012,3(3):868-873. |
| APA | Li M,Liu Z,Ren JS,&Qu XG.(2012).Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates.chemical science,3(3),868-873. |
| MLA | Li M,et al."Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates".chemical science 3.3(2012):868-873. |
入库方式： OAI收割
来源：长春应用化学研究所
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