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Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues

文献类型：期刊论文

作者Wang, Lei2; Liu, Bin2; Liu, Yuxue1; Sun, Yue2; Liu, Wujun3; Yu, Dayu2; Zhao, Zongbao K.1
刊名ORGANIC LETTERS
出版日期2019-05-03
卷号21期号:9页码:3218-3222
ISSN号1523-7060
DOI10.1021/acs.orglett.9b00935
通讯作者Yu, Dayu(yudy@neepu.edu.cn) ; Zhao, Zongbao K.(zhaozb@dicp.ac.cn)
英文摘要An Escherichia coli strain was constructed for the efficient import of nicotinamide adenine dinucleotide (NAD) analogues into cells by limiting extracellular degradation while expressing an efficient NAD importer. In vivo functions of three NAD analogues were characterized. Nicotinamide hypoxanthine dinucleotide was identified as an inhibitor of NAD synthesis. Nicotinamide cytosine dinucleotide had excellent biocompatibility and was used for characterizing a growth-dependent degradation of in vivo nicotinamide cofactors.
WOS关键词NAD(+) TRANSPORTER ; COFACTORS ; IDENTIFICATION ; IMPORT
资助项目National Natural Science Foundation of China[21708003] ; National Natural Science Foundation of China[31470787] ; National Natural Science Foundation of China[21837002] ; Science and Technology Research Project of Jilin Province, China[20170519015JH]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000467320000052
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/172060]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Yu, Dayu; Zhao, Zongbao K.
作者单位1.Chinese Acad Sci, Div Biotechnol, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Northeast Elect Power Univ, Sch Chem Engn, Jilin 132012, Peoples R China
3.Dalian Med Univ, Inst Canc Stem Cell, Dalian 116044, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Lei,Liu, Bin,Liu, Yuxue,et al. Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues[J]. ORGANIC LETTERS,2019,21(9):3218-3222.
APA Wang, Lei.,Liu, Bin.,Liu, Yuxue.,Sun, Yue.,Liu, Wujun.,...&Zhao, Zongbao K..(2019).Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues.ORGANIC LETTERS,21(9),3218-3222.
MLA Wang, Lei,et al."Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues".ORGANIC LETTERS 21.9(2019):3218-3222.

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来源：大连化学物理研究所

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