pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy
文献类型：期刊论文
| 作者 | Qin, Ya-Ting2; Peng, Hui2; He, Xi-Wen2; Li, Wen-You2,3; Zhang, Yu-Kui1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2019-09-18 |
| 卷号 | 11期号:37页码:34268-34281 |
| 关键词 | ZIF-8 Si-Gd nanoparticles chemo-/photodynamic imaging drug delivery |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.9b12641 |
| 通讯作者 | Li, Wen-You(wyli@mail.nankai.edu.cn) |
| 英文摘要 | A multifunctional diagnosis and treatment integration platform is crucial in cancer treatments. Here, we show that by integrating Gd-doped silicon nanoparticles (Si-Gd NPs), chlorine e6 (Ce6), doxorubicin (DOX), zeolitic imidazolate framework-8 (ZIF-8), poly(2-(diethylamino)ethyl methacrylate) polymers (HOOC-PDMAEMA-SH), and folic acid-polyethylene glycol)-maleimide (MaL-PEG-FA) into one single nanoplatform by a self-assembly method, novel multifunctional MOFs (named FZIF-8/DOX-PD-FA) are synthesized with great biocompatibility and tumor targeting as well as pH responsiveness and no drug leakage for drug delivery. In the design, Si-Gd NPs and Ce6 embedded in the nanocomposites are used for magnetic resonance and fluorescence dual-modal imaging, respectively. DOX loaded by the FZIF-8/DOX-PD-FA porous structure is used for chemotherapy, while Ce6 is excited by near-infrared radiation (NIR) for photodynamic therapy. In addition, the pH-responsive ability of HOOC-PDMAEMA-SH to effectively prevent drug leakage is demonstrated by drug release studies in vitro. From the results of confocal microscopy imaging in vitro and fluorescence/magnetic resonance imaging in vivo, FZIF-8/DOX-PD-FA showed a targeting effect on MCF-7 cancer cells. More importantly, the results of treatment experiments on tumor-bearing mice showed that the tumor volume of the FZIF-8/DOX-PD-FA + NIR group is decreased the most compared to the original volume. Owing to the unique dual-modal imaging capability and excellent chemo-/photodynamic combinational cancer therapy effect, the present hybrid nanocarrier provides a new research platform for a new generation of theranostic nanoparticles. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; ONE-POT SYNTHESIS ; SILICON NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ROOM-TEMPERATURE ; ANTICANCER DRUG ; GRAPHENE OXIDE ; DELIVERY ; DOXORUBICIN ; CARRIER |
| 资助项目 | National Natural Science Foundation of China[21775077] ; National Natural Science Foundation of China[21475069] ; Tianjin Natural Science Foundation[16JCZDJC37200] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000487179900081 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/172636]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Wen-You |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China 2.Nankai Univ, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 3.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Ya-Ting,Peng, Hui,He, Xi-Wen,et al. pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(37):34268-34281. |
| APA | Qin, Ya-Ting,Peng, Hui,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2019).pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,11(37),34268-34281. |
| MLA | Qin, Ya-Ting,et al."pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 11.37(2019):34268-34281. |
入库方式： OAI收割
来源：大连化学物理研究所
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