Reductive methylation labeling, from quantitative to structural proteomics
文献类型：期刊论文
| 作者 | Liu, Zheyi1; Zhou, Ye1; Liu, Jing3; Chen, Jin1; Heck, Albert J. R.2; Wang, Fangjun1 |
| 刊名 | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 118页码:771-778 |
| ISSN号 | 0165-9936 |
| 关键词 | Reductive methylation Stable isotope dimethyl labeling Mass spectrometry Quantitative proteomics N-termini profiling Structural proteomics Lysine reactivity profiling |
| DOI | 10.1016/j.trac.2019.07.009 |
| 通讯作者 | Wang, Fangjun(wangfj@dicp.ac.cn) |
| 英文摘要 | Reductive methylation is a highly reactive and selective chemical labeling method and plays an important role in proteomic analysis. Various applications of reductive methylation have been developed and have substantially promoted the scope of proteomic analysis to date. Aside from a well-known method for introducing isotopes, this reaction could also be conducted under biological conditions and has little structural perturbations. In this paper, we reviewed the recent developments and applications of reductive methylation in quantitative proteomics and protein N-terminal profiling, along with the emerging applications in structural proteomics for monitoring protein structural/conformational changes under various conditions. (C) 2019 Elsevier B.V. All rights reserved. |
| WOS关键词 | PROTEIN N-TERMINI ; FORMALDEHYDE-INDUCED MODIFICATIONS ; CHEMICAL CROSS-LINKING ; MASS-SPECTROMETRY ; PHOSPHOPROTEOME ANALYSIS ; AMINO-ACID ; IDENTIFICATION ; LYSINE ; ENRICHMENT ; THROUGHPUT |
| 资助项目 | National Key R&D Program of China[2016YFF0200504] ; National Natural Science Foundation of China[91853101] ; National Natural Science Foundation of China[21675152] ; National Natural Science Foundation of China[81702995] ; DICP[ZZBS201603] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000486383900060 |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/172827]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Wang, Fangjun |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Bijvoet Ctr Biomol Res, Biomol Mass Spectrometry & Prote, Padualaan 8, NL-3584 CH Utrecht, Netherlands 3.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zheyi,Zhou, Ye,Liu, Jing,et al. Reductive methylation labeling, from quantitative to structural proteomics[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,118:771-778. |
| APA | Liu, Zheyi,Zhou, Ye,Liu, Jing,Chen, Jin,Heck, Albert J. R.,&Wang, Fangjun.(2019).Reductive methylation labeling, from quantitative to structural proteomics.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,118,771-778. |
| MLA | Liu, Zheyi,et al."Reductive methylation labeling, from quantitative to structural proteomics".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 118(2019):771-778. |
入库方式： OAI收割
来源：大连化学物理研究所
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