Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
文献类型：期刊论文
| 作者 | Ma, Zhenhua1,2; Wang, Xiaomei2; Yin, Peiyuan; Wu, Ruihong2,3; Zhou, Lina3; Xu, Guowang3; Niu, Junqi2 |
| 刊名 | MEDICINE
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 98期号:31页码:11 |
| 关键词 | bile acid biomarkers drug induced liver injury serum metabolic profiling UHPLC-MS/MS |
| ISSN号 | 0025-7974 |
| DOI | 10.1097/MD.0000000000016717 |
| 通讯作者 | Xu, Guowang(xugw@dicp.ac.cn) ; Niu, Junqi(junqi_niu@163.com) |
| 英文摘要 | This study aims to determine the non-invasive, reliable and sensitive biochemical parameters for the diagnosis of drug-induced liver injury (DILI). Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and selected reaction monitoring (SRM) were used to profile the serum metabolome and quantify 15 targeted bile acid metabolites, respectively, in samples obtained from 38 DILI patients and 30 healthy controls. A comparison of the resulting serum metabolome profiles of the study participants revealed significant differences between DILI patients and healthy controls. Specifically, serum palmitic acid, taurochenodeoxycholic acid, glycocholic acid (GCA), and tauroursodeoxycholic acid (TUDCA) levels were significantly higher, and serum lysophosphatidylethanolamine levels were significantly lower in DILI patients vs healthy controls (P<.001). Furthermore, the SRM assay of bile acids revealed that the increase in GCA, taurocholic acid (TCA), TUDCA, glycochenodeoxycholic acid (GCDCA), glycochenodeoxycholic sulfate (GCDCS), and taurodeoxycholic acid (TDCA) corresponded to a higher degree of liver damage. These results also indicate that serum concentrations of chenodeoxycholic acid (CDCA), deoxycholic acid (DCA) and lithocholic acid (LCA) were significantly lower in patients with severe DILI, when compared to healthy controls, and that this decrease was closely correlated to the severity of liver damage. Taken together, these results demonstrate that bile acids could serve as potential biomarkers for the early diagnosis and severity of DILI. |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA ; CAUSALITY ASSESSMENT ; MASS-SPECTROMETRY ; ADVERSE REACTIONS ; HEPATITIS-B ; MODEL ; METABONOMICS ; INFLAMMATION ; HEPATOCYTES ; VALIDATION |
| 资助项目 | National Basic Research Program of China (973 Program)[2015CB554304] ; National Natural Science Foundation of China[81373057] ; Health and Family Planning Commission Project of Jilin Province[2016Q043] |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000483216200065 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 资助机构 | National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/172953]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang; Niu, Junqi |
| 作者单位 | 1.Beihua Univ, Affiliated Hosp, Dept Hepatol, Jilin, Jilin, Peoples R China 2.Jilin Univ, Hosp 1, Dept Hepatol, Changchun, Jilin, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Zhenhua,Wang, Xiaomei,Yin, Peiyuan,et al. Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury[J]. MEDICINE,2019,98(31):11. |
| APA | Ma, Zhenhua.,Wang, Xiaomei.,Yin, Peiyuan.,Wu, Ruihong.,Zhou, Lina.,...&Niu, Junqi.(2019).Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury.MEDICINE,98(31),11. |
| MLA | Ma, Zhenhua,et al."Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury".MEDICINE 98.31(2019):11. |
入库方式： OAI收割
来源：大连化学物理研究所
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